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Table 4 Suggestive linkage results for ECG and HRV phenotypes

From: Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study

phenotype

maximum LOD

SNP

chromosome

position (Mb)

1.5 LOD CI

ECG

     

PR

2.98

rs1011725

4

124.75

113.07 – 138.58

QT

2.52

rs10512617

17

74.21

66.43 – 76.22

QT

2.50

rs164462

3

8.72

5.49 – 13.81

HRV

     

LF/HF

2.39

rs10519165

15

75.51

67.57 – 79.33

TP

2.19

rs10500600

11

4.40

0.80 – 11.77

  1. Shown are the linkage results exceeding a maximum multipoint LOD score of 2.0 for electrocardiographic QT, RR and PR intervals and the ratio of low frequency to high frequency power, total power and the standard deviation of normal RR intervals. The SNP at the maximum LOD score is shown as well as the confidence interval spanning the 1.5 LOD drop from the maximum.
  2. Mb = megabase; CI = confidence interval; ECG = electrocardiogram; PR = PR interval adjusted for age, sex, RR interval; QT = QT interval adjusted for age, sex, RR interval; HRV = heart rate variability; LF/HF = ratio of low frequency to high frequency power; TP = total power.
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BMC Medical Genetics

ISSN: 1471-2350

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