Skip to main content

Table 3 Top GEE association results for electrocardiographic phenotypes

From: Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study

Trait

SNP rank

rs ID

Chromosome

Physical Position

GEE p-value

FBAT p-value

Gene region (within 60 kb)

Top 8 QT interval SNPs

    

QT

1

rs10507380

13

26777526

8.4 × 10 -6

0.665

RPL21

QT

2

rs2726920

11

108252434

4.2 × 10 -5

0.865

DDX10

QT

3

rs763552

8

31564949

4.7 × 10 -5

0.033

NRG1

QT

4

rs366307

5

150527337

4.9 × 10 -5

0.104

ANXA6

QT

5

rs3858646

12

114038413

7.7 × 10 -5

1.3 × 10-4

 

QT

6

rs1558139

19

15858564

8.2 × 10 -5

6.0 × 10-5

CYP4F2

QT

7

rs1695508

7

28739796

8.5 × 10 -5

0.002

 

QT

8

rs10495588

2

12153871

8.7 × 10 -5

0.001

 

Top 8 RR interval SNPs

    

RR

1

rs2179896

14

53945264

1.7 × 10 -5

0.032

 

RR

2

rs10518674

15

50105438

1.9 × 10 -5

0.033

MAPK6

RR

3

rs321967

7

77959200

2.6 × 10 -5

0.018

MAGI2

RR

4

rs4319121

8

53668308

3.6 × 10 -5

0.571

 

RR

5

rs844429

10

80016392

4.5 × 10 -5

0.032

 

RR

6

rs4345013

22

25706391

4.9 × 10 -5

0.227

 

RR

7

rs2643191

3

165861395

5.2 × 10 -5

2.5 × 10-4

 

RR

8

rs2932529

1

112905406

5.7 × 10 -5

0.232

CAPZA1

Top 8 PR interval SNPs

    

PR

1

rs882300

2

136809987

3.2 × 10 -7

0.133

 

PR

2

rs10518795

15

53131579

1.1 × 10 -5

0.062

 

PR

3

rs7201988

16

9516007

3.0 × 10 -5

0.001

 

PR

4

rs2096767

11

102296609

3.1 × 10 -5

0.031

MMP13

PR

5

rs2831936

21

28922444

3.1 × 10 -5

0.011

 

PR

6

rs10516736

4

82325666

5.1 × 10 -5

0.014

BMP3

PR

7

rs4488182

11

41032137

5.4 × 10 -5

0.008

 

PR

8

rs10489798

1

96957067

6.2 × 10 -5

0.086

PTBP2

Top 8 LF/HF SNPs

    

LF/HF

1

rs1395479

4

178693340

6.9 × 10 -6

0.034

NEIL3

LF/HF

2

rs2215456

12

40596176

1.3 × 10 -5

0.002

 

LF/HF

3

rs1336938

13

88369006

1.6 × 10 -5

0.003

 

LF/HF

4

rs796184

13

88515431

1.9 × 10 -5

0.003

 

LF/HF

5

rs4669749

2

11643262

2.0 × 10 -5

0.113

GREB1

LF/HF

6

rs1871841

8

13674417

2.1 × 10 -5

0.015

 

LF/HF

7

rs721691

7

128485610

3.0 × 10 -5

0.026

 

LF/HF

8

rs10509700

10

97884521

4.2 × 10 -5

0.864

 

Top 8 Total Power SNPs

    

TP

1

rs9315385

13

35561302

7.7 × 10 -6

0.031

DCAMKL1

TP

2

rs2276886

4

77285607

1.5 × 10 -5

0.004

CXCL9

TP

3

rs726698

2

35366992

2.2 × 10 -5

0.001

 

TP

4

rs1330948

13

106192232

2.4 × 10 -5

0.016

 

TP

5

rs2283064

7

125719004

3.0 × 10 -5

0.042

GRM8

TP

6

rs10515199

5

74135390

3.8 × 10 -5

0.113

 

TP

7

rs1407709

1

184794336

4.0 × 10 -5

0.042

 

TP

8

rs1723482

2

47318190

5.5 × 10 -5

0.040

 

Top 8 SDNN SNPs

    

SDNN

1

rs2966762

5

109411118

2.0 × 10 -5

0.024

 

SDNN

2

rs286751

5

107430837

2.1 × 10 -5

4.1 × 10-5

FBXL17

SDNN

3

rs1013621

8

52963944

4.0 × 10 -5

0.018

 

SDNN

4

rs1378506

5

109419129

4.5 × 10 -5

0.110

 

SDNN

5

rs1866559

2

27247237

5.3 × 10 -5

0.405

CGREF1

SDNN

6

rs2049161

18

4117583

5.9 × 10 -5

0.036

 

SDNN

7

rs9297393

8

108356753

6.4 × 10 -5

0.587

ANGPT1

SDNN

8

rs7012655

8

52740967

8.4 × 10 -5

0.007

 
  1. The top 8 association results for ECG phenotypes QT, RR and PR interval and for HRV phenotypes low frequency to high frequency power (LF/HF), total power (TP) and standard deviation of normal RR intervals (SDNN) are shown from a total 70,987 SNPs tested in additive genetic models using GEE. Chromosome and physical position using NCBI build 35 reference sequence (hg17) are shown. The corresponding FBAT p-value is shown (note: the number of informative families varies substantially). Genes within 60 kb of a SNP are shown.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us