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Table 1 Heritability of electrocardiographic and heart rate variability phenotypes examined in the Framingham 100K project

From: Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study

Phenotype

Acronym

Heritability sample

Original Exam

Offspring Exam

Adjustment*

Heritability† (SE)

Electrocardiographic phenotypes

QT sex-pooled

QTPOOL

1951

11

1

Age, RR, sex, cohort

0.39 (0.04)†

QT men only

QTMEN**

900

11

1

Age, RR, cohort

0.43 (0.08)

QT women only

QTWOMEN**

1051

11

1

Age, RR, cohort

0.46 (0.04)

RR sex-pooled

RRPOOL

1951

11

1

Age, sex, cohort

0.29 (0.04)

RR men only

RRMEN**

900

11

1

Age, cohort

0.28 (0.08)

RR women only

RRWOMEN**

1051

11

1

Age, cohort

0.31 (0.07)

PR sex-pooled

PRAdjRRPOOL

1950

11

1

Age, RR, sex, cohort

0.34 (0.04)

Heart rate variability phenotypes

SDNN sex-pooled

SDNNHRV

747

18

3

Age, heart rate, SBP, DBP, coffee & alcohol intake

0.32 (0.09)†

Total power sex-pooled

TOTPWRHRV

747

18

3

Age, heart rate, SBP, DBP, coffee & alcohol intake

0.41 (0.10)†

Low frequency/high frequency power sex-pooled

LFHFHRV

747

18

3

Age, heart rate, SBP, DBP, coffee & alcohol intake

0.36 (0.10)†

  1. All phenotypes for ECG and HRV traits are shown (including pre-specified secondary traits not examined for this report), including covariates adjusted for in linear regression models. Heritability estimates were generated in the superset of individuals with phenotype values in families (n ≤ 1951 for ECG traits, n ≤ 747 for HRV traits). For electrocardiographic traits there were 1175 individuals with genotypes and for heart rate variability there were 548 individuals with genotypes in the 100K analyses. All results are publicly available at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007.
  2. *Separate regression models were created by cohort and sex for ECG and HRV measures. †All heritability estimates <0.001.
  3. **Prespecified secondary results in GWAS pipeline but not analyzed in this report (available at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007). QT and HRV heritability estimates are consistent with previous reports in largely overlapping sample [9,16].