From: Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
Candidate gene | Total number of SNPs* | SNPs with p value < 0.05 | Phenotype | GEE p value | FBAT p value |
---|---|---|---|---|---|
Major CVD/Major CHD | |||||
ALOX5 | 5 | 0 | Â | Â | Â |
ALOX5AP | 23 | rs7983138 | Major CHD | 0.011 | 0.373 |
 |  | rs2985183 | Major CHD | 0.014 | 0.455 |
 |  | rs7984952 | Major CHD | 0.015 | 0.266 |
 |  | rs117395 | Major CHD | 0.016 | 0.568 |
 |  | rs4603405 | Major CHD | 0.018 | 0.257 |
 |  | rs10507391 | Major CHD | 0.028 | 0.660 |
 |  | rs10507391 | Major CVD | 0.043 | 0.878 |
 |  | rs7995384 | Major CHD | 0.049 | 0.967 |
GJA4 | 14 | rs618675 | Major CHD | 0.004 | 0.169 |
 |  | rs10489658 | Major CHD | 0.004 | 0.145 |
 |  | rs618675 | Major CVD | 0.009 | 0.464 |
 |  | rs10493062 | Major CHD | 0.011 | 0.051 |
 |  | rs768586 | Major CHD | 0.016 | 0.135 |
 |  | rs10489658 | Major CVD | 0.025 | 0.237 |
 |  | rs10489656 | Major CHD | 0.520 | 0.030 |
 |  | rs10489656 | Major CVD | 0.538 | 0.044 |
 |  | rs2093185 | Major CVD | 0.547 | 0.019 |
 |  | rs6686484 | Major CHD | 1.000 | 0.031 |
LGALS2 | 1 | 0 | Â | Â | Â |
LTA | 2 | 0 | Â | Â | Â |
LTA4H | 22 | rs10492225 | Major CHD | 0.013 | 0.080 |
MEF2A | 5 | rs2033546 | Major CVD | 0.004 | 0.006 |
 |  | rs2863274 | Major CVD | 0.006 | 0.006 |
 |  | rs2033546 | Major CHD | 0.016 | 0.013 |
 |  | rs2863274 | Major CHD | 0.062 | 0.021 |
MMP3 | 17 | rs2096767 | Major CVD | 0.028 | 0.506 |
 |  | rs2096767 | Major CHD | 0.032 | 0.610 |
 |  | rs566125 | Major CVD | 0.042 | 0.079 |
SERPINE1 | 2 | 0 | Â | Â | Â |
PCSK9 | 11 | rs2114580 | Major CHD | 0.010 | 0.075 |
 |  | rs2114580 | Major CVD | 0.026 | 0.057 |
 |  | rs2317951 | Major CVD | 0.076 | 0.002 |
 |  | rs2317951 | Major CHD | 0.077 | 0.002 |
 |  | rs2317948 | Major CHD | 0.478 | 0.029 |
 |  | rs2317948 | Major CVD | 0.584 | 0.026 |
THBS2 | 7 | rs911839 | Major CVD | 0.192 | 0.035 |
 |  | rs911839 | Major CHD | 0.255 | 0.032 |
THBS4 | 16 | rs264986 | Major CHD | 0.443 | 0.048 |
VAMP8 | 5 | 0 | Â | Â | Â |
Atrial fibrillation | |||||
ACE | 3 | 0 | Â | Â | Â |
AGT | 13 | rs758216 | Â | 0.041 | 0.204 |
GJA5 | 13 | 0 | Â | Â | Â |
KCNE2 | 14 | 0 | Â | Â | Â |
KCNH2 | 6 | 0 | Â | Â | Â |
KCNJ2 | 23 | rs10512574 | Â | 0.140 | 0.041 |
KCNQ1 | 5 | rs10488674 | Â | 0.136 | 0.046 |
KCNE1 | 20 | rs7277304 | Â | 0.745 | 0.047 |
 |  | rs9305551 |  | 0.119 | 0.018 |
Heart failure | |||||
ABCC9 | 8 | 0 | Â | Â | Â |
ACTC | 15 | rs752876 | Â | 0.065 | 0.040 |
ADRB1 | 12 | 0 | Â | Â | Â |
ADRB2 | 18 | rs40949 | Â | 0.545 | 0.025 |
 |  | rs185021 |  | 0.947 | 0.040 |
ADRBK1 | 0 | - | Â | Â | Â |
ATP2A2 | 3 | 0 | Â | Â | Â |
CALML3 | 2 | 0 | Â | Â | Â |
CTF1 | 0 | - | Â | Â | Â |
DES | 2 | 0 | Â | Â | Â |
DSP | 15 | rs10484326 | Â | 0.671 | 0.029 |
LDB3 | 0 | - | Â | Â | Â |
LMNA | 5 | 0 | Â | Â | Â |
MYBPC3 | 4 | 0 | Â | Â | Â |
MYH6 | 1 | 0 | Â | Â | Â |
MYH7 | 2 | 0 | Â | Â | Â |
MYL2 | 3 | 0 | Â | Â | Â |
MYL3 | 1 | 0 | Â | Â | Â |
PLN | 16 | rs3951042 | Â | 0.025 | 0.083 |
 |  | rs724868 |  | 0.055 | 0.039 |
 |  | rs9320660 |  | 0.063 | 0.034 |
 |  | rs10484286 |  | 0.074 | 0.043 |
SGCD | 37 | 0 | Â | Â | Â |
TNNC1 | 4 | rs1133415 | Â | 0.040 | 0.131 |
TNNI3 | 1 | 0 | Â | Â | Â |
TNNT2 | 9 | rs832177 | Â | 0.015 | 0.164 |
TPM1 | 7 | rs10519186 | Â | 0.011 | 0.085 |
 |  | rs902027 |  | 0.152 | 0.011 |
TTN | 13 | rs10497521 | Â | 0.705 | 0.030 |
VCL | 3 | 0 | Â | Â | Â |