Skip to main content

Table 4 Association Results for Pre-Specified Candidate Genes

From: Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes

Candidate gene

Total number of SNPs*

SNPs with p value < 0.05

Phenotype

GEE p value

FBAT p value

Major CVD/Major CHD

ALOX5

5

0

   

ALOX5AP

23

rs7983138

Major CHD

0.011

0.373

  

rs2985183

Major CHD

0.014

0.455

  

rs7984952

Major CHD

0.015

0.266

  

rs117395

Major CHD

0.016

0.568

  

rs4603405

Major CHD

0.018

0.257

  

rs10507391

Major CHD

0.028

0.660

  

rs10507391

Major CVD

0.043

0.878

  

rs7995384

Major CHD

0.049

0.967

GJA4

14

rs618675

Major CHD

0.004

0.169

  

rs10489658

Major CHD

0.004

0.145

  

rs618675

Major CVD

0.009

0.464

  

rs10493062

Major CHD

0.011

0.051

  

rs768586

Major CHD

0.016

0.135

  

rs10489658

Major CVD

0.025

0.237

  

rs10489656

Major CHD

0.520

0.030

  

rs10489656

Major CVD

0.538

0.044

  

rs2093185

Major CVD

0.547

0.019

  

rs6686484

Major CHD

1.000

0.031

LGALS2

1

0

   

LTA

2

0

   

LTA4H

22

rs10492225

Major CHD

0.013

0.080

MEF2A

5

rs2033546

Major CVD

0.004

0.006

  

rs2863274

Major CVD

0.006

0.006

  

rs2033546

Major CHD

0.016

0.013

  

rs2863274

Major CHD

0.062

0.021

MMP3

17

rs2096767

Major CVD

0.028

0.506

  

rs2096767

Major CHD

0.032

0.610

  

rs566125

Major CVD

0.042

0.079

SERPINE1

2

0

   

PCSK9

11

rs2114580

Major CHD

0.010

0.075

  

rs2114580

Major CVD

0.026

0.057

  

rs2317951

Major CVD

0.076

0.002

  

rs2317951

Major CHD

0.077

0.002

  

rs2317948

Major CHD

0.478

0.029

  

rs2317948

Major CVD

0.584

0.026

THBS2

7

rs911839

Major CVD

0.192

0.035

  

rs911839

Major CHD

0.255

0.032

THBS4

16

rs264986

Major CHD

0.443

0.048

VAMP8

5

0

   

Atrial fibrillation

ACE

3

0

   

AGT

13

rs758216

 

0.041

0.204

GJA5

13

0

   

KCNE2

14

0

   

KCNH2

6

0

   

KCNJ2

23

rs10512574

 

0.140

0.041

KCNQ1

5

rs10488674

 

0.136

0.046

KCNE1

20

rs7277304

 

0.745

0.047

  

rs9305551

 

0.119

0.018

Heart failure

ABCC9

8

0

   

ACTC

15

rs752876

 

0.065

0.040

ADRB1

12

0

   

ADRB2

18

rs40949

 

0.545

0.025

  

rs185021

 

0.947

0.040

ADRBK1

0

-

   

ATP2A2

3

0

   

CALML3

2

0

   

CTF1

0

-

   

DES

2

0

   

DSP

15

rs10484326

 

0.671

0.029

LDB3

0

-

   

LMNA

5

0

   

MYBPC3

4

0

   

MYH6

1

0

   

MYH7

2

0

   

MYL2

3

0

   

MYL3

1

0

   

PLN

16

rs3951042

 

0.025

0.083

  

rs724868

 

0.055

0.039

  

rs9320660

 

0.063

0.034

  

rs10484286

 

0.074

0.043

SGCD

37

0

   

TNNC1

4

rs1133415

 

0.040

0.131

TNNI3

1

0

   

TNNT2

9

rs832177

 

0.015

0.164

TPM1

7

rs10519186

 

0.011

0.085

  

rs902027

 

0.152

0.011

TTN

13

rs10497521

 

0.705

0.030

VCL

3

0

   
  1. *Includes all SNPs within 200 kb upstream of start to 200 kb downstream of end of gene, with genotype call rate ≥0.8; minor allele frequency ≥0.1; HWE p ≥ 0.001.
  2. Data are sorted by GEE additive genetic effects model with FBAT results provided alongside.