From: Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
Phenotype | Definition | Number of individuals | Number with event | Adjustment* |
---|---|---|---|---|
Major CVD | Myocardial infarction, coronary insufficiency, CHD death, or atherothrombotic stroke | 1345 | 142 | Age, sex; Multivariable: Age, sex, smoking, diabetes, systolic BP, anti-hypertensive therapy, total cholesterol |
Major CHD | Myocardial infarction, coronary insufficiency, or CHD death | 1345 | 118 | Same as Major CVD |
Heart failure | Heart failure, hospitalized or non-hospitalized | 1345 | 73 | Same as Major CVD except BMI added, total cholesterol removed |
Atrial fibrillation | Atrial fibrillation or atrial flutter on ECG | 1341 | 151 | Age, sex; Multivariable: Age, sex, diabetes, systolic BP, anti-hypertensive therapy, valve disease |