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Table 1 Phenotype definitions

From: Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes

Phenotype

Definition

Number of individuals

Number with event

Adjustment*

Major CVD

Myocardial infarction, coronary insufficiency, CHD death, or atherothrombotic stroke

1345

142

Age, sex; Multivariable: Age, sex, smoking, diabetes, systolic BP, anti-hypertensive therapy, total cholesterol

Major CHD

Myocardial infarction, coronary insufficiency, or CHD death

1345

118

Same as Major CVD

Heart failure

Heart failure, hospitalized or non-hospitalized

1345

73

Same as Major CVD except BMI added, total cholesterol removed

Atrial fibrillation

Atrial fibrillation or atrial flutter on ECG

1341

151

Age, sex; Multivariable: Age, sex, diabetes, systolic BP, anti-hypertensive therapy, valve disease

  1. * Covariates in cohort-stratified proportional-hazards models for time to event