Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

BMC Medical Genetics

Table 5 Results for Pre-Specified Candidate Genes

Candidate gene	Total number of SNPs*	SNPs with p value < 0.05	Phenotype	GEE p value	FBAT p value
Diastolic blood pressure
ACE	3	0
AGT	13	rs2478518		0.021	0.186
AGTR1	17	0
CYP11B2	1	0
NR3C2	26	rs6845733		0.008	0.399
REN	9	0
Systolic blood pressure
ACE	3	0
AGT	13	rs2478518		0.003	0.275
AGTR1	17	0
CYP11B2	1	0
NR3C2	26	rs6845733		0.010	0.323
		rs3916013		0.024	0.598
REN	9	0
Arterial stiffness
ACE	3	0
AGT	13	rs731824	MAP	0.022	0.397
		rs2478518	FW	0.024	0.688
		rs2478516	FW	0.037	0.217
		rs2478516	RW	0.046	0.663
AGTR1	17	rs1059502	MAP	0.025	0.023
		rs427832	FW	0.046	0.963
CYP11B2	1	rs2717594	CF-PWV	0.003	0.308
NR3C2	26	rs3910046	CF-PWV	0.009	0.383
		rs9307847	CB-PWV	0.011	0.741
		rs3910046	CB-PWV	0.014	0.409
		rs10519959	CB-PWV	0.018	0.175
		rs3846317	RW	0.021	0.649
		rs4835136	CB-PWV	0.027	0.268
		rs3846318	RW	0.042	0.293
		rs10519958	RW	0.049	0.529
REN	9	rs16776	FW	0.012	0.115
		rs3911890	FW	0.022	0.207

*Includes all SNPs within 200 kb of start to 200 kb beyond end of gene, with genotype call rate >= 0.8; minor allele frequency >= 0.1; HWE p >= 0.001
CB-PWV = carotid-brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; DBP = diastolic blood pressure; FW = forward wave amplitude; MAP = mean arterial pressure; RW = reflected wave amplitude; SBP = systolic blood pressure

ISSN: 1471-2350