Skip to main content

Table 5 Results for Pre-Specified Candidate Genes

From: Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

Candidate gene Total number of SNPs* SNPs with p value < 0.05 Phenotype GEE p value FBAT p value
Diastolic blood pressure
ACE 3 0    
AGT 13 rs2478518   0.021 0.186
AGTR1 17 0    
CYP11B2 1 0    
NR3C2 26 rs6845733   0.008 0.399
REN 9 0    
Systolic blood pressure
ACE 3 0    
AGT 13 rs2478518   0.003 0.275
AGTR1 17 0    
CYP11B2 1 0    
NR3C2 26 rs6845733   0.010 0.323
   rs3916013   0.024 0.598
REN 9 0    
Arterial stiffness
ACE 3 0    
AGT 13 rs731824 MAP 0.022 0.397
   rs2478518 FW 0.024 0.688
   rs2478516 FW 0.037 0.217
   rs2478516 RW 0.046 0.663
AGTR1 17 rs1059502 MAP 0.025 0.023
   rs427832 FW 0.046 0.963
CYP11B2 1 rs2717594 CF-PWV 0.003 0.308
NR3C2 26 rs3910046 CF-PWV 0.009 0.383
   rs9307847 CB-PWV 0.011 0.741
   rs3910046 CB-PWV 0.014 0.409
   rs10519959 CB-PWV 0.018 0.175
   rs3846317 RW 0.021 0.649
   rs4835136 CB-PWV 0.027 0.268
   rs3846318 RW 0.042 0.293
   rs10519958 RW 0.049 0.529
REN 9 rs16776 FW 0.012 0.115
   rs3911890 FW 0.022 0.207
  1. *Includes all SNPs within 200 kb of start to 200 kb beyond end of gene, with genotype call rate >= 0.8; minor allele frequency >= 0.1; HWE p >= 0.001
  2. CB-PWV = carotid-brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; DBP = diastolic blood pressure; FW = forward wave amplitude; MAP = mean arterial pressure; RW = reflected wave amplitude; SBP = systolic blood pressure
\