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Table 4 Top Results for Geometric Means of SBP and DBP Considered Jointly (at examinations 1, 7 and in the long term), and arterial stiffness phenotypes considered jointly.

From: Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

SNP

Exam

Chr.

Position

P value

Gene

DBP and SBP

rs10493340

1

1

63,303,150

1.49 × 10-5

 

rs9321764

7

6

140,532,157

2.89 × 10-5

 

rs10491334

7

5

110,800,303

3.74 × 10-5

CAMK4

rs2121070

1

14

75,720,517

3.96 × 10-5

C14orf118

rs1328925

1

4

159,547,895

4.22 × 10-5

TMEM144

rs10510079

1

10

122,473,101

7.27 × 10-5

 

rs7562854

7

2

12,149,816

7.52 × 10-5

 

rs1841055

7

4

70,039,785

7.63 × 10-5

UGT2A3

rs10485320

7

6

47,884,860

7.75 × 10-5

OPN5

rs9298203

7

8

73,270,276

8.28 × 10-5

 

Arterial stiffness

rs10518082

7

4

72,282,885

0.002

DCK

rs1322512

7

6

153,040,067

0.005

SYNE1

rs10511389

7

3

120,557,547

0.007

CDGAP

rs883524

7

8

23,250,536

0.008

LOXL2

rs965674

7

5

82,518,340

0.008

XRCC4

rs10502173

7

11

112,708,233

0.009

TTC12

rs1468512

7

17

64,731,363

0.010

ABCA10

rs4075701

7

2

116,146,020

0.011

 

rs10496604

7

2

123,501,987

0.011

 

rs770189

7

5

88,124,195

0.011

MEF2C

  1. Based on Additive genetic effects model using GEE and minor allele frequency of 0.1, call rate >= 0.80 and HWE p value >= 0.001