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Table 3 Results of GEE General Genetic Effects Model for Long-term Average Blood Pressure Phenotypes and Arterial Stiffness

From: Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

Phenotype SNP Chr. Position P value* Gene
Diastolic Blood Pressure (long-term average)
DBP rs7591163 2 228,423,620 2.90 × 10-7 CCL20, WDR69
DBP rs1901167 5 40,996,921 6.40 × 10-5 C7
DBP rs6829806 4 85,916,019 8.10 × 10-5 CDS1
DBP rs6796000 3 189,874,213 1.10 × 10-4 LPP
DBP rs3096277 16 82,321,705 1.40 × 10-4 CDH13
DBP rs969049 4 99,346,035 1.40 × 10-4  
DBP rs10503497 8 14,326,753 1.40 × 10-4 SGCZ
DBP rs2262138 19 16,213,403 2.10 × 10-4 FAM32A, AP1M1
DBP rs10509333 10 72,737,658 3.70 × 10-4 UNC5B, SLC29A3
DBP rs933296 12 109,837,230 4.10 × 10-4 MYL2
Systolic Blood Pressure (long-term average)
SBP rs3096277 16 82,321,705 9.90 × 10-8 CDH13
SBP rs1721359 2 228,460,118 1.00 × 10-5 CCL20, WDR69
SBP rs225942 14 29,595,139 5.30 × 10-5 PRKD1
SBP rs298988 4 119,867,850 7.80 × 10-5 SEC24D
SBP rs10514096 5 76,700,940 1.10 × 10-4 PDE8B
SBP rs10512245 9 95,771,366 1.40 × 10-4  
SBP rs294593 5 163,000,000 1.80 × 10-4 MAT2B
SBP rs6085660 20 6,639,069 1.90 × 10-4 BMP2
SBP rs6796000 3 190,000,000 2.20 × 10-4 LPP
SBP rs575121 12 117,000,000 2.20 × 10-4 TAOK3
Tonometry
MAP rs3773643 3 30,685,247 1.99 × 10-7 TGFBR2
FW rs3793427 8 17,188,201 1.96 × 10-6 VPS37A
RW rs6492654 13 92,688,671 2.28 × 10-6 GPC6
CF-PWV rs1367248 2 124,734,834 2.88 × 10-6 CNTNAP5
CF-PWV rs10521232 17 13,480,529 3.88 × 10-6 HS3ST3A1
FW rs3766680 1 173,563,0070 4.15 × 10-6 TNR
RW rs1371924 3 144,732,760 4.44 × 10-6 SLC9A9
RW rs10488172 7 132,985,716 8.49 × 10-6 EXOC4
FW rs10507534 13 44,724,220 1.05 × 10-5 GTF2F2
FW rs719856 6 47,702,681 1.21 × 10-5 CD2AP
  1. *P values from 2 degree of freedom test
  2. CB-PWV = carotid-brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; DBP = diastolic blood pressure; FW = forward wave amplitude; MAP = mean arterial pressure; RW = reflected wave amplitude; SBP = systolic blood pressure
  3. Minor allele frequency >= 0.20, HWE P value >= 0.05, call rate >= 0.80
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