Table 3 Results of GEE General Genetic Effects Model for Long-term Average Blood Pressure Phenotypes and Arterial Stiffness
Phenotype | SNP | Chr. | Position | P value* | Gene |
|---|---|---|---|---|---|
Diastolic Blood Pressure (long-term average) | |||||
DBP | rs7591163 | 2 | 228,423,620 | 2.90 × 10-7 | CCL20, WDR69 |
DBP | rs1901167 | 5 | 40,996,921 | 6.40 × 10-5 | C7 |
DBP | rs6829806 | 4 | 85,916,019 | 8.10 × 10-5 | CDS1 |
DBP | rs6796000 | 3 | 189,874,213 | 1.10 × 10-4 | LPP |
DBP | rs3096277 | 16 | 82,321,705 | 1.40 × 10-4 | CDH13 |
DBP | rs969049 | 4 | 99,346,035 | 1.40 × 10-4 | |
DBP | rs10503497 | 8 | 14,326,753 | 1.40 × 10-4 | SGCZ |
DBP | rs2262138 | 19 | 16,213,403 | 2.10 × 10-4 | FAM32A, AP1M1 |
DBP | rs10509333 | 10 | 72,737,658 | 3.70 × 10-4 | UNC5B, SLC29A3 |
DBP | rs933296 | 12 | 109,837,230 | 4.10 × 10-4 | MYL2 |
Systolic Blood Pressure (long-term average) | |||||
SBP | rs3096277 | 16 | 82,321,705 | 9.90 × 10-8 | CDH13 |
SBP | rs1721359 | 2 | 228,460,118 | 1.00 × 10-5 | CCL20, WDR69 |
SBP | rs225942 | 14 | 29,595,139 | 5.30 × 10-5 | PRKD1 |
SBP | rs298988 | 4 | 119,867,850 | 7.80 × 10-5 | SEC24D |
SBP | rs10514096 | 5 | 76,700,940 | 1.10 × 10-4 | PDE8B |
SBP | rs10512245 | 9 | 95,771,366 | 1.40 × 10-4 | |
SBP | rs294593 | 5 | 163,000,000 | 1.80 × 10-4 | MAT2B |
SBP | rs6085660 | 20 | 6,639,069 | 1.90 × 10-4 | BMP2 |
SBP | rs6796000 | 3 | 190,000,000 | 2.20 × 10-4 | LPP |
SBP | rs575121 | 12 | 117,000,000 | 2.20 × 10-4 | TAOK3 |
Tonometry | |||||
MAP | rs3773643 | 3 | 30,685,247 | 1.99 × 10-7 | TGFBR2 |
FW | rs3793427 | 8 | 17,188,201 | 1.96 × 10-6 | VPS37A |
RW | rs6492654 | 13 | 92,688,671 | 2.28 × 10-6 | GPC6 |
CF-PWV | rs1367248 | 2 | 124,734,834 | 2.88 × 10-6 | CNTNAP5 |
CF-PWV | rs10521232 | 17 | 13,480,529 | 3.88 × 10-6 | HS3ST3A1 |
FW | rs3766680 | 1 | 173,563,0070 | 4.15 × 10-6 | TNR |
RW | rs1371924 | 3 | 144,732,760 | 4.44 × 10-6 | SLC9A9 |
RW | rs10488172 | 7 | 132,985,716 | 8.49 × 10-6 | EXOC4 |
FW | rs10507534 | 13 | 44,724,220 | 1.05 × 10-5 | GTF2F2 |
FW | rs719856 | 6 | 47,702,681 | 1.21 × 10-5 | CD2AP |