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Table 1 Phenotype List

From: Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

   Exam cycle/s   
  N* Offspring Cohort Adjustment Covariates
Primary Phenotypes
Blood Pressure
SBP 1 2 1 12 Age and sex, multivariable Cohort, sex, age, BMI
SBP 7 2 7 26 Age and sex, multivariable Cohort, sex, age, BMI
SBP 1–7 2 Mean of exams 1–7 Mean of exams 12, 16, 18, 20, 22, 24, 26 Age and sex, multivariable Cohort, sex, age, BMI
DBP 1 2 1 12 Age and sex, multivariable Cohort, sex, age, BMI
DBP 7 2 7 26 Age and sex, multivariable Cohort, sex, age, BMI
DBP 1–7 2 Mean of exams 1–7 Mean of exams 12, 16, 18, 20, 22, 24, 26 Age and sex, multivariable Cohort, sex, age, BMI
Tonometry
Carotid-femoral PWV 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
Carotid-brachial PWV 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
Forward pressure wave 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
Reflected pressure wave 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
Mean arterial pressure 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
Secondary Phenotypes^
Blood Pressure
DBP 2 2 2 16 Age and sex, multivariable Cohort, sex, age, BMI
DBP 3 2 3 18 Age and sex, multivariable Cohort, sex, age, BMI
DBP 4 2 4 20 Age and sex, multivariable Cohort, sex, age, BMI
DBP 5 2 5 22 Age and sex, multivariable Cohort, sex, age, BMI
DBP 6 2 6 24 Age and sex, multivariable Cohort, sex, age, BMI
SBP 2 2 2 16 Age and sex, multivariable Cohort, sex, age, BMI
SBP 3 2 3 18 Age and sex, multivariable Cohort, sex, age, BMI
SBP4 2 4 20 Age and sex, multivariable Cohort, sex, age, BMI
SBP 5 2 5 22 Age and sex, multivariable Cohort, sex, age, BMI
SBP 6 2 6 24 Age and sex, multivariable Cohort, sex, age, BMI
PP 1 2 1 12 Age and sex, multivariable Cohort, sex, age, BMI
PP 2 2 2 16 Age and sex, multivariable Cohort, sex, age, BMI
PP 3 2 3 18 Age and sex, multivariable Cohort, sex, age, BMI
PP 4 2 4 20 Age and sex, multivariable Cohort, sex, age, BMI
PP 5 2 5 22 Age and sex, multivariable Cohort, sex, age, BMI
PP 6 2 6 24 Age and sex, multivariable Cohort, sex, age, BMI
PP 7 2 7 26 Age and sex, multivariable Cohort, sex, age, BMI
PP 1–7 2 Mean of exams 1–7 Mean of exams 12, 16, 18, 20, 22, 24, 26 Age and sex, multivariable Cohort, sex, age, BMI
Tonometry
1/CF-PWV 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
AI 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
CPP 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
CR-PWV 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
DBP-osc 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
PA-1 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
PA-2 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
PP-osc 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
RWTT 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
SBP-osc 2 7 Not included Age and sex, multivariable Sex, age, age^2, height, weight
  1. *n = number of phenotypes analyzed
  2. ^Association results for primary and secondary phenotypes are available on the worldwide web at: http://web.ncbi.nlm.nih.gov/projects/gap/framingham/cgi-bin/study.cgi?id=phs000007
  3. AI = augmentation index; CPP = central pulse pressure; CB-PWV = carotid brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; CR-PWV = carotid-radial pulse wave velocity; DBP = diastolic blood pressure; DBP-osc = brachial DBP by oscillometric device; FW = forward wave amplitude; MAP = mean arterial pressure; PA-1 = apparent peripheral amplification; PA-2 = true peripheral amplification; PP = pulse pressure; PP-osc = brachial PP by oscillometric device; RW = reflected wave amplitude; RWTT = reflected wave transit time; SBP = systolic blood pressure; SBP-osc = brachial SBP by oscillometric device; 1/CF-PWV = inverse of CF-PWV.
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