Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

Vasan, Ramachandran S; Larson, Martin G; Aragam, Jayashri; Wang, Thomas J; Mitchell, Gary F; Kathiresan, Sekar; Newton-Cheh, Christopher; Vita, Joseph A; Keyes, Michelle J; O'Donnell, Christopher J; Levy, Daniel; Benjamin, Emelia J

doi:10.1186/1471-2350-8-S1-S2

Table 4 Associations of traits with SNPs in or near (up to 200 kb away) 6 well-replicated genes in the published literature with a p-value < 0.05 in either FBAT or GEE.

From: Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

4A. Associations of averaged echo traits
Candidate Gene	FHS 100K SNP	Physical Position	Trait	GEE p-value	FBAT p-value
*ACE*	no SNP was associated with a p value < 0.05 for any LV trait studies
*ADRB1*	rs10510001	115962372	LV diastolic dimension	0.004	0.0002
	rs10510001	115962372	LV systolic dimension	0.001	0.001
	rs10510000	115961985	LV diastolic dimension	0.052	0.001
	rs10510000	115961985	LV systolic dimension	0.059	0.001
	rs7902873	115884949	LV diastolic dimension	0.467	0.002
	rs10509999	115917269	LV diastolic dimension	0.136	0.003
	rs180940	115712401	LV wall thickness	0.003	0.072
	rs180934	115720720	LV wall thickness	0.005	0.090
	rs180935	115720249	LV wall thickness	0.005	0.160
	rs998334	115957002	LV diastolic dimension	0.289	0.005
	rs7902873	115884949	LV systolic dimension	0.249	0.006
	rs10509999	115917269	LV systolic dimension	0.036	0.008
	rs180935	115720249	LV mass	0.011	0.409
	rs180934	115720720	LV mass	0.015	0.411
	rs7902873	115884949	LV mass	0.646	0.016
	rs998334	115957002	LV systolic dimension	0.110	0.018
	rs10510001	115962372	LV fractional shortening	0.021	0.056
	rs10510000	115961985	LV fractional shortening	0.382	0.027
	rs180940	115712401	LV mass	0.029	0.303
	rs10510001	115962372	LV mass	0.393	0.040
	rs6585258	115739125	LV mass	0.047	0.481
	rs10510000	115961985	LV mass	0.335	0.048
*AGT*	rs10495300	227188497	Left atrial diameter	0.095	0.001
	rs2478518	227174605	LV fractional shortening	0.028	0.238
	rs1202585	227309949	LV wall thickness	0.030	0.028
	rs2180478	227295655	LV diastolic dimension	0.800	0.030
	rs758216	227005969	Aortic root diameter	0.031	0.341
	rs1202524	227257907	LV diastolic dimension	0.323	0.037
	rs2478518	227174605	LV systolic dimension	0.038	0.467
	rs731824	227329806	Left atrial diameter	0.043	0.399
	rs1202585	227309949	LV mass	0.044	0.117
*AGTR1*	rs1059502	150045008	Aortic root diameter	0.598	0.005
	rs1357424	149801524	LV fractional shortening	0.075	0.006
	rs1357424	149801524	LV systolic dimension	0.241	0.030
	rs1059502	150045008	LV diastolic dimension	0.142	0.030
	rs2331406	150048180	Aortic root diameter	0.589	0.032
	rs10513333	149786557	Left atrial diameter	0.437	0.039
*VEGF*	rs729761	43912549	LV fractional shortening	0.012	0.200
	rs729761	43912549	Left atrial diameter	0.573	0.018
	rs729761	43912549	LV systolic dimension	0.018	0.249
	rs2396083	43912786	LV fractional shortening	0.026	0.250
	rs2396083	43912786	Left atrial diameter	0.489	0.031
	rs2396083	43912786	LV systolic dimension	0.040	0.224
*NOS3*	No SNP was associated with a p value < 0.05 for any LV trait studied
4B. Associations of ETT traits
Candidate Gene	FHS 100K SNP	Physical Position	Trait	GEE p-value	FBAT p-value
*ACE*	rs10491167	58780430	Stage 2 Exercise systolic blood pressure	0.046	0.137
	rs10491168	58795195	Stage 2 Exercise systolic blood pressure	0.030	0.124
	rs721575	59136652	Post-exercise 3 minute recovery heart rate	0.024	0.025
*ADRB1*	rs2419857	115607366	Stage 2 Exercise heart rate	0.852	0.030
	rs4345919	115651155	Post-exercise 3 minute recovery heart rate	0.048	0.740
*AGT*	rs1752189	227000046	Post-exercise 3 minute recovery SBP	0.145	0.021
	rs758216	227005969	Post-exercise 3 minute recovery SBP	0.184	0.050
	rs10495298	227120049	Stage 2 Exercise systolic blood pressure	0.288	0.050
	rs2478516	227175387	Stage 2 Exercise systolic blood pressure	0.021	0.486
*AGTR1*	rs275678	149851039	Post-exercise 3 minute recovery SBP	0.216	0.049
	rs427832	149949061	Post-exercise 3 minute recovery SBP	0.014	0.171
	rs1949350	150089423	Stage 2 Exercise heart rate	0.010	0.335
*VEGF*	rs729761	43912549	Stage 2 Exercise heart rate	0.041	0.035
*NOS3*	rs2303928	150176978	Stage 2 Exercise heart rate	0.012	0.056
4C. Associations of BA function traits
Candidate Gene	FHS 100K SNP	Physical Position	Trait	GEE p-value	FBAT p-value
*ACE*	no SNP was associated with a p value < 0.05
*ADRB1*	rs180940	115712401	BA hyperemic flow velocity	0.581	0.015
	rs180935	115720249	BA hyperemic flow velocity	0.953	0.030
	rs180934	115720720	BA hyperemic flow velocity	0.662	0.029
	rs10509999	115917269	BA hyperemic flow velocity	0.001	0.137
	rs10510000	115961985	BA hyperemic flow velocity	0.007	0.014
	rs10510001	115962372	BA hyperemic flow velocity	0.017	0.239
*AGT*	rs758216	227005969	Baseline BA flow velocity	0.049	0.488
	rs1202585	227309949	Baseline BA diameter	0.002	0.080
	rs1202585	227309949	BA hyperemic flow velocity	0.049	0.080
*AGTR1*	rs1492090	149884751	BA hyperemic flow velocity	0.026	0.293
	rs427832	149949061	Baseline BA flow velocity	0.509	0.043
*VEGF*	rs833048	43762514	BA hyperemic flow velocity	0.860	0.036
	rs10498756	44046909	BA hyperemic flow velocity	0.312	0.008
*NOS3*	rs741067	149938103	Baseline BA diameter	0.043	0.024
	rs1006581	149949571	Baseline BA diameter	0.009	0.097
	rs2215564	150001612	BA hyperemic flow velocity	0.028	0.104

dbSNP positions are from NCBI Build 35 (hg17).

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ISSN: 1471-2350

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