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Table 3 Top associations ordered by geometric mean of GEE p-values across traits (3 groups) and across examinations (echo traits)

From: Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

Trait

SNP

Chromosome

Physical position

GEE p-value

In/near Gene (within 60 kb)

IA. Top 15 SNPs associated with Echocardiographic Traits across individual exams

LV diastolic dimension

rs4920799

5

84642284

0.001

 

LV diastolic dimension

rs1379659

4

20296952

0.001

SLIT2

Aortic root diameter

rs26438

5

165221499

0.001

 

LV mass

rs473664

15

51598287

0.0016

WDR72

Aortic root diameter

rs10488825

11

81688520

0.0017

 

LV mass

rs10498091

2

221724949

0.0017

 

LV diastolic dimension

rs10514431

16

76498035

0.0018

KIAA1576

LV diastolic dimension

rs10505599

8

133812159

0.0019

FLJ33069

LV systolic dimension

rs10504543

8

73941196

0.0019

KCNB2

LV diastolic dimension

rs2900208

12

11769731

0.0019

ETV6

LV mass

rs861857

22

20306894

0.0022

UBE2L3

LV systolic dimension

rs10501940

11

99440078

0.0023

CNTN5

LV systolic dimension

rs707025

2

155014031

0.0023

GALNT13

Aortic root diameter

rs1395204

18

4477509

0.0025

 

LV diastolic dimension

rs10513272

9

116143601

0.0026

PAPPA

IB. Top 15 SNPs associated with Averaged Echocardiographic Traits (across LV traits)

Across LV phenotypes

rs1379659

4

20296952

0.0007

SLIT2

 

rs10498091

2

221724949

0.0009

 
 

rs861857

22

20306894

0.001

UBE2L3

 

rs473664

15

51598287

0.0012

WDR72

 

rs3766377

1

157613632

0.0016

CD244

 

rs10504543

8

73941196

0.0017

KCNB2

 

rs10518462

4

126562521

0.0018

 
 

rs1959289

14

86208319

0.0026

 
 

rs667269

3

175822307

0.0027

 
 

rs1959290

14

86208482

0.0027

 
 

rs1959291

14

86208525

0.0027

 
 

rs10485104

6

165966351

0.0030

PDE10A

 

rs10491574

9

116701992

0.0030

ASTN2

 

rs707025

2

155014031

0.0032

GALNT13

 

rs525960

1

149310939

0.0033

LCE5A

II. Top 5 SNPs associated with ETT Traits (across traits)

Across phenotypes

rs1560916

17

28973892

0.0101

ACCN1

 

rs1432214

2

137712255

0.0106

 
 

rs10512056

9

76835140

0.0112

LOC442425

 

rs2056387

1

234250153

0.0115

RYR2

 

rs6560812

10

2363105

0.0132

 

III. Top 5 SNPs associated with BA endothelial Traits (across traits)

Across phenotypes

rs2912991

7

52684247

0.0029

 
 

rs10510677

3

36168070

0.007

 
 

rs10493052

1

33614778

0.007

ZNF31

 

rs7155941

14

41681710

0.008

 
 

rs1954627

14

41689011

0.009

 
  1. dbSNP positions are from NCBI Build 35 (hg17).
  2. Abbreviations as in Table 1.