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Table 4 (a) Comparison of mean BMI and mean WC Results with prior literature for SNPs that are either present in the 100K or in LD with a SNP in the 100K; (b) Associations of mean BMI and mean WC with all SNPs in or near genes (up to 200 kb away) for 5 well-replicated genes in the published literature (INSIG, PPARG, ADIPOQ, ESR1, LEP)* with a p-value < 0.05 in either FBAT or GEE**

From: Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project

4a. Comparison of mean BMI and mean WC Results with prior literature for SNPs that are either present in the 100K or in LD with a SNP in the 100K

       

Mean BMI p-value

Mean WC p-value

Gene

Candidate SNP

100K SNP

Location Candidate SNP (bp)

Location 100K SNP (bp)

D. prime

r2

FBAT

GEE

FBAT

GEE

INSIG2

rs7566605

Rs7566605

118552255

118552255

1

1

0.449

0.001

0.975

0.480

ESR1-Xba1

rs9340799

rs3853250

152255495

152252014

1

0.62

0.047

0.350

0.980

0.105

 

rs9340799

rs3853251

152255495

152252870

1

0.96

0.309

0.963

0.333

0.336

LEP

rs1349419

rs10487506

127471164

127472106

1

0.69

0.422

0.583

0.788

0.848

 

rs12535747

rs10487505

127472286

127454114

0.83

0.34

0.188

0.286

0.420

0.975

 

rs12535747

rs10487506

127472286

127472106

1

0.48

0.422

0.583

0.788

0.848

PPARG

rs1801282

rs1801282

12368125

12368125

1

1

0.556

0.178

0.290

0.406

4b. Associations of mean BMI and mean WC with all SNPs in or near genes (up to 200 kb away) for 5 well-replicated genes in the published literature (INSIG, PPARG, ADIPOQ, ESR1, LEP)* with a p-value < 0.05 in either FBAT or GEE**

   

Mean BMI p-value

Mean WC p-value

    

Gene

SNP

Physical Position (bp)

FBAT

GEE

FBAT

GEE

    

INSIG

rs9284719

118395025

0.148

0.035

0.510

0.925

    
 

rs3771942

118425080

0.766

0.005

0.812

0.984

    
 

rs10490628

118446520

0.464

0.021

0.765

0.238

    
 

rs7566605

118552255

0.449

0.001

0.975

0.480

    

PPARG

rs2938392

12409608

0.158

0.003

0.644

0.244

    
 

rs709157

12437024

0.602

0.106

0.091

0.023

    
 

rs10510422

12505413

0.806

0.546

0.044

0.720

    
 

rs10510423

12526881

0.986

0.753

0.038

0.787

    
 

rs2454431

12558068

0.806

0.034

0.268

0.882

    
 

rs963163

12632067

0.997

0.047

0.749

0.036

    

ADIPOQ

rs1042464

187878274

0.962

0.231

0.024

0.722

    

ESR1

rs851982

152117099

0.880

0.538

0.119

0.043

    
 

rs10484922

152224431

0.318

0.012

0.067

0.528

    
 

rs3853250

152252014

0.047

0.350

0.980

0.105

    
 

rs3778099

152510689

0.033

0.367

0.513

0.689

    
 

rs9322361

152551257

0.020

0.096

0.122

0.522

    
  1. *No SNPs in the LEP gene had a p-value < 0.05
  2. **The following number of SNPs were evaluated in the INSIG, PPARG, ADIPOQ, ESR1, and LEP genes: 19, 28, 16, 37, 4
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BMC Medical Genetics

ISSN: 1471-2350

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