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Table 2 (a) Top association results for mean BMI and mean WC based on GEE p-value; (b) Top 25 association results for mean BMI and mean WC based on FBAT p-value; (c) LOD scores of at least 2.0 with accompanying LOD score 1.5 support interval for mean BMI and mean WC

From: Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project

Trait

SNP

Chromosome

Physical Position (Mb)

GEE p-value

FBAT p-value

Gene

2a. Top association results for mean BMI and mean WC based on GEE p-value

Mean BMI

rs1106683

7

130910780

1.2*10-07

3.2*10-04

 

Mean WC

rs4471028

8

75457530

2.0*10-07

3.2*10-04

GDAP1

Mean WC

rs4469448

8

75457665

2.6*10-07

0.003

GDAP1

Mean WC

rs6996971

8

75455047

4.9*10-07

0.002

GDAP1

Mean WC

rs10504576

8

75429234

7.1*10-07

0.005

GDAP1

Mean WC

rs1875517

3

118790257

1.5*10-06

0.002

 

Mean BMI

rs1106684

7

130910920

1.6*10-06

0.002

 

Mean BMI

rs1333026

13

65018785

8.1*10-06

0.209

 

Mean BMI

rs2296465

10

3299647

1.5*10-05

0.262

 

Mean BMI

rs1374489

5

19658900

1.6*10-05

0.348

CDH18

Mean WC

rs1466113

17

68676913

2.7*10-05

0.004

SSTR2

Mean BMI

rs10486301

7

18183021

2.7*10-05

0.016

 

Mean BMI

rs2221880

5

19420500

3.0*10-05

0.072

 

Mean WC

rs1456873

4

62130929

3.1*10-05

0.005

 

Mean BMI

rs10513097

5

11406101

4.4*10-05

0.022

CTNND2

Mean BMI

rs2361128

19

62431059

4.4*10-05

0.004

ZNF264

Mean BMI

rs2942329

5

19429660

4.5*10-05

0.089

 

Mean WC

rs4129319

4

88752564

4.7*10-05

0.003

SPARCL1

Mean BMI

rs10509361

10

77223192

5.2*10-05

0.044

C10orf11

Mean BMI

rs2967001

5

19422000

6.0*10-05

0.074

 

Mean BMI

rs464766

3

162570294

6.1*10-05

0.072

ADMP

Mean BMI

rs10487263

7

123603987

7.0*10-05

0.036

 

Mean BMI

rs4922571

11

31643025

7.0*10-05

0.062

ELP4

Mean BMI

rs7013836

8

5666540

8.2*10-05

0.103

 

Mean BMI

rs7202384

16

13658225

8.2*10-05

0.002

 

2b. Top 25 association results for mean BMI and mean WC based on FBAT p-value

Trait

SNP

Chromosome

Physical Location (Mb)

GEE p-value

FBAT p-value

Gene

Mean WC

rs10488165

7

132594899

0.011

2.6*10-06

SEC8L1

Mean WC

rs2206682

6

56001938

0.011

4.2*10-06

COL21A1

Mean WC

rs2223662

6

56001756

0.013

5.1*10-06

COL21A1

Mean WC

rs953536

9

111569442

0.007

8.2*10-06

C9orf84

Mean WC

rs10517461

4

37789743

2.3*10-04

2.9*10-05

TBC1D1

Mean WC

rs7941883

11

123262095

0.084

3.0*10-05

OR8D4|OR4D5|OR6T1

Mean BMI

rs10503776

8

25765786

0.009

3.8*10-05

EBF2

Mean BMI

rs711702

3

22956280

0.143

4.0*10-05

 

Mean WC

rs4312989

6

55918441

0.075

4.2*10-05

 

Mean WC

rs10519381

5

113700141

0.01

4.4*10-05

KCNN2

Mean WC

rs10483872

14

75239061

0.018

4.5*10-05

KIAA0998

Mean WC

rs315711

9

111628006

0.008

5.4*10-05

C9orf84

Mean WC

rs4715571

6

55917006

0.03

5.9*10-05

 

Mean WC

rs667463

9

111647315

0.004

7.0*10-05

C9orf84

Mean BMI

rs7320523

13

67552774

0.193

7.4*10-05

 

Mean WC

rs3752591

22

40664016

0.001

8.5*10-05

C22orf18

Mean WC

rs1496389

5

113753570

0.018

9.8*10-05

KCNN2

Mean WC

rs1619682

7

133453958

0.14

1.0*10-04

SLC35B4

Mean BMI

rs10492197

12

66871874

0.038

1.0*10-04

IFNG|IL26|IL22

Mean WC

rs10501467

11

79913437

0.037

1.1*10-04

 

Mean WC

SNP_A-1731932

1

24035982

0.152

1.1*10-04

 

Mean BMI

rs10512326

9

103934100

0.063

1.2*10-04

SMC2L1

Mean BMI

rs7533902

1

97791249

0.029

1.2*10-04

DPYD

Mean BMI

rs2870950

12

66870973

0.034

1.2*10-04

IFNG|IL26|IL22

Mean WC

rs2226351

21

25259810

1.8*10-04

1.3*10-04

 

2c. LOD scores of at least 2.0 with accompanying LOD score 1.5 support interval for mean BMI and mean WC

Trait

SNP

Chromosome

Physical Position (bp)

LOD

LOD1.5 Lower Bound (bp)

LOD1.5 Upper Bound (bp)

Mean BMI

rs9309153

2

48856798

2.3125

44048379

64579948

Mean WC

rs1992901

2

121386899

2.2721

116579748

132195205

Mean BMI

rs10518418

1

89149134

2.0053

51727132

99668198