A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

BMC Medical Genetics

Table 3 GEE results for 4 correlated phenotypes (ApoA-I, LDLNMRsm, MeanHDL-C, and MeanTG), ranked by proportion of GEE P < 0.01*

rs id	Chr	Physical Position	GEE P ApoA-I	GEE P LDLNMRsm	GEE P MeanHDL-C	GEE P MeanTG	Gene Symbol
rs505717	19	42122156	7.8*10^-4	0.003	1.3*10^-6	0.04	ZNF568
rs3734678	6	107639853	4.7*10^-4	0.18	8.2*10^-6	0.006	PDSS2
rs2256038	21	15443047	0.11	0.002	8.8*10^-4	6.4*10^-5
rs10486788	7	15788581	4.7*10^-4	0.005	8.5*10^-4	0.01
rs232885	1	58824078	0.86	0.002	9.6*10^-4	5.7*10^-4	AB067502
rs4982795	14	23294875	0.001	1.9*10^-7	0.001	0.11
rs524802	19	42138787	0.001	0.003	7.6*10^-7	0.02	ZNF568
rs544543	19	42122663	0.001	0.004	2.5*10^-4	0.03	ZNF568
rs2823097	21	15445015	0.10	0.004	0.002	8.0*10^-5
rs1394041	3	148579545	0.02	0.003	0.002	5.6*10^-5
rs10499320	7	2906624	0.001	0.001	8.8*10^-4	0.03
rs2889195	1	65868751	6.6*10^-4	0.003	0.003	0.02
rs7007797	8	19921250	0.01	0.02	5.0*10^-4	0.002
rs7597861	2	100311705	0.08	0.004	1.0*10^-4	0.006
rs6063858	20	50715959	0.04	3.0*10^-4	0.002	0.003
rs2425524	20	40750358	0.01	0.05	3.6*10^-4	0.008
rs1509384	2	22556488	8.5*10^-4	0.01	0.007	0.03
rs9317760	13	68480686	0.003	0.05	6.6*10^-4	0.002
rs6804032	3	116031161	0.002	0.02	0.009	8.7*10^-4
rs8069913	17	13812167	0.03	0.009	0.001	6.7*10^-4

*All SNPs in this table had GEE association P values < 0.01 for at least three of the four traits (ApoA-I, LDLNMRsm, MeanHDL-C, and MeanTG). No SNPs in our dataset had GEE association P values < 0.01 for all four traits.

ISSN: 1471-2350