From: Genome-wide association with diabetes-related traits in the Framingham Heart Study
Candidate Gene | Candidate SNP | Physical Position | FHS 100K SNP | Physical Position | r2 | GEE lowest p-value | GEE Trait | FBAT Lowest p-value | FBAT Trait | Cox p-value | Cox HR for DM |
---|---|---|---|---|---|---|---|---|---|---|---|
ABCC8 | rs757110 | 17375053 | rs878208 | 17478662 | 0.04 | 0.05 | Fasting insulin | 0.12 | Fasting insulin | 0.02 | 1.96 |
 |  |  | rs722341 | 17429722 | 0.05 | 0.11 | tFPG | 0.009 | HbA1c | 0.70 | 1.09 |
 |  |  | rs916829 | 17397049 | 0.02 | 0.18 | Fasting insulin | 0.02 | Fasting insulin | 0.47 | 0.84 |
 |  |  | rs2283257 | 17446021 | 0.03 | 0.23 | ISI_0-120 | 0.05 | ISI_0-120 | 0.98 | 0.99 |
 |  |  | rs2299641 | 17397566 | 0.01 | 0.38 | Fasting insulin | 0.21 | ISI_0-120 | 0.19 | 1.24 |
 |  |  | rs2190454 | 17490211 | 0.01 | 0.35 | Fasting insulin | 0.25 | ISI_0-120 | 0.48 | 0.90 |
PPARG | rs1801282 | 12368125 | rs10510422 | 12505413 | 0.00 | 0.003 | tFPG | 0.13 | ISI_0-120 | 0.13 | 3.86 |
 |  |  | rs3856808 | 12505184 | 0.00 | 0.005 | tFPG | 0.17 | ISI_0-120 | 0.11 | 0.25 |
 |  |  | rs10510421 | 12502242 | 0.00 | 0.006 | tFPG | 0.14 | ISI_0-120 | 0.12 | 0.26 |
 |  |  | rs2938392 | 12409608 | 0.03 | 0.007 | Fasting insulin | 0.14 | Fasting insulin | 0.36 | 1.13 |
 |  |  | rs709157 | 12526881 | 0.00 | 0.05 | ISI_0-120 | 0.10 | ISI_0-120 | 0.68 | 0.93 |
 |  |  | rs10510418 | 12363563 | 0.04 | 0.07 | Fasting insulin | 0.10 | ISI_0-120 | 0.46 | 0.89 |
 |  |  | rs1801282 | 12368125 | 1.00 | 0.07 | ISI_0-120 | 0.20 | HbA1c | 0.89 | 0.96 |
 |  |  | rs1899951 | 12369840 | 1.00 | 0.11 | ISI_0-120 | 0.25 | HbA1c | 0.86 | 0.96 |
 |  |  | rs4135268 | 12525199 | 0.01 | 0.11 | ISI_0-120 | 0.20 | tFPG | 0.80 | 0.92 |
 |  |  | rs10510417 | 12352294 | 0.31 | 0.17 | ISI_0-120 | 0.45 | ISI_0-120 | 0.62 | 0.91 |
 |  |  | rs2292101 | 12409901 | 0.00 | 0.19 | tFPG | 0.22 | Fasting insulin | 0.08 | 1.62 |
 |  |  | rs10510419 | 12401936 | 0.01 | 0.26 | tFPG | 0.35 | ISI_0-120 | 0.24 | 1.31 |
 |  |  | rs10510410 | 12321738 | 0.31 | 0.38 | FPG | 0.36 | Fasting insulin | 0.88 | 0.97 |
 |  |  | rs10510411 | 12321849 | 0.31 | 0.40 | FPG | 0.39 | Fasting insulin | 0.94 | 0.99 |
 |  |  | rs10510412 | 12321962 | 0.31 | 0.44 | FPG | 0.38 | Fasting insulin | 0.84 | 1.03 |
 | rs12255372* | 114798892 | rs10509967 | 114685922 | 0.00 | 0.04 | HbA1c | 0.12 | ISI_0-120 | 0.82 | 0.96 |
TCF7L2 | rs7903146* | 114748339 | rs7100927 | 114786038 | 0.50 | 0.03 | tFPG | 0.13 | tFPG | 0.007 | 1.56 |
 |  |  | rs10509966 | 114666170 | 0.00 | 0.04 | HbA1c | 0.07 | ISI_0-120 | 0.64 | 1.09 |
 |  |  | rs10509969 | 114903549 | 0.08 | 0.14 | Fasting insulin | 0.08 | FPG | 0.60 | 0.89 |
 |  |  | rs290483 | 114905204 | 0.10 | 0.17 | Fasting insulin | 0.34 | tFPG | 0.93 | 0.99 |
 |  |  | rs7917983 | 114722872 | 0.09 | 0.27 | tFPG | 0.29 | HbA1c | 0.17 | 0.82 |
 |  |  | rs10509970 | 114904903 | 0.05 | 0.32 | tFPG | 0.43 | tFPG | 0.51 | 1.14 |