Skip to main content

Table 4 FHS 100K SNP Test of Association with SNPs in Established Candidate Genes for Type 2 Diabetes

From: Genome-wide association with diabetes-related traits in the Framingham Heart Study

Candidate Gene

Candidate SNP

Physical Position

FHS 100K SNP

Physical Position

r2

GEE lowest p-value

GEE Trait

FBAT Lowest p-value

FBAT Trait

Cox p-value

Cox HR for DM

ABCC8

rs757110

17375053

rs878208

17478662

0.04

0.05

Fasting insulin

0.12

Fasting insulin

0.02

1.96

   

rs722341

17429722

0.05

0.11

tFPG

0.009

HbA1c

0.70

1.09

   

rs916829

17397049

0.02

0.18

Fasting insulin

0.02

Fasting insulin

0.47

0.84

   

rs2283257

17446021

0.03

0.23

ISI_0-120

0.05

ISI_0-120

0.98

0.99

   

rs2299641

17397566

0.01

0.38

Fasting insulin

0.21

ISI_0-120

0.19

1.24

   

rs2190454

17490211

0.01

0.35

Fasting insulin

0.25

ISI_0-120

0.48

0.90

PPARG

rs1801282

12368125

rs10510422

12505413

0.00

0.003

tFPG

0.13

ISI_0-120

0.13

3.86

   

rs3856808

12505184

0.00

0.005

tFPG

0.17

ISI_0-120

0.11

0.25

   

rs10510421

12502242

0.00

0.006

tFPG

0.14

ISI_0-120

0.12

0.26

   

rs2938392

12409608

0.03

0.007

Fasting insulin

0.14

Fasting insulin

0.36

1.13

   

rs709157

12526881

0.00

0.05

ISI_0-120

0.10

ISI_0-120

0.68

0.93

   

rs10510418

12363563

0.04

0.07

Fasting insulin

0.10

ISI_0-120

0.46

0.89

   

rs1801282

12368125

1.00

0.07

ISI_0-120

0.20

HbA1c

0.89

0.96

   

rs1899951

12369840

1.00

0.11

ISI_0-120

0.25

HbA1c

0.86

0.96

   

rs4135268

12525199

0.01

0.11

ISI_0-120

0.20

tFPG

0.80

0.92

   

rs10510417

12352294

0.31

0.17

ISI_0-120

0.45

ISI_0-120

0.62

0.91

   

rs2292101

12409901

0.00

0.19

tFPG

0.22

Fasting insulin

0.08

1.62

   

rs10510419

12401936

0.01

0.26

tFPG

0.35

ISI_0-120

0.24

1.31

   

rs10510410

12321738

0.31

0.38

FPG

0.36

Fasting insulin

0.88

0.97

   

rs10510411

12321849

0.31

0.40

FPG

0.39

Fasting insulin

0.94

0.99

   

rs10510412

12321962

0.31

0.44

FPG

0.38

Fasting insulin

0.84

1.03

 

rs12255372*

114798892

rs10509967

114685922

0.00

0.04

HbA1c

0.12

ISI_0-120

0.82

0.96

TCF7L2

rs7903146*

114748339

rs7100927

114786038

0.50

0.03

tFPG

0.13

tFPG

0.007

1.56

   

rs10509966

114666170

0.00

0.04

HbA1c

0.07

ISI_0-120

0.64

1.09

   

rs10509969

114903549

0.08

0.14

Fasting insulin

0.08

FPG

0.60

0.89

   

rs290483

114905204

0.10

0.17

Fasting insulin

0.34

tFPG

0.93

0.99

   

rs7917983

114722872

0.09

0.27

tFPG

0.29

HbA1c

0.17

0.82

   

rs10509970

114904903

0.05

0.32

tFPG

0.43

tFPG

0.51

1.14

  1. * LD betweaen rs12255372 and rs7903146 in HapMap CEU: r2 = 0.78; Bold = r2 >= 0.5 or p-value < 0.05