Genome-wide association with diabetes-related traits in the Framingham Heart Study

Meigs, James B; Manning, Alisa K; Fox, Caroline S; Florez, Jose C; Liu, Chunyu; Cupples, L Adrienne; Dupuis, Josée

doi:10.1186/1471-2350-8-S1-S16

BMC Medical Genetics

Table 3 Forty two (42) SNPs associated with (FPG, HbA1c, and tFPG) OR (fasting insulin, HOMA-IR, and ISI_0-120) OR (any two of either) AND incident DM

From: Genome-wide association with diabetes-related traits in the Framingham Heart Study

No.	Chr	SNP	N other SNPs with r² > 0.8	Minor Allele A/G/T/C	MAF	Gene *	Gene Position	GEE Mean p-value		FBAT Mean p-value		Cox p-value	Minor Allele Cox HR for DM	FBAT DM Incidence p-value
								3 Glucose Traits	3 Insulin Traits	3 Glucose Traits	3 Insulin Traits
1	12	rs1368254	135	G	48.3%	LOC387882	Near	0.02	0.001	0.01	0.007	0.007	0.67	0.0008
2	12	rs10506806	76	T	29.7%		Out	0.003	0.03	0.01	0.01	0.02	0.65	0.004
3	2	rs10496417	74	A	34.5%	SLC5A7	Near	0.01	0.003	0.04	0.02	0.007	1.58	0.11
4	8	rs10503835	8	C	21.9%	HMBOX1	In	0.004	0.03	0.03	0.008	0.005	0.59	0.03
5	5	rs459743	83	C	16.9%		Out	0.009	0.009	0.03	0.02	0.002	0.42	0.012
6	10	rs1879316	55	A	13.5%	RASGEF1A	Near	0.004	0.001	0.18	0.07	0.009	0.45	0.48
7	13	rs2066219	79	G	23.0%		Out	0.005	0.0009	0.22	0.08	0.009	0.59	0.22
8	7	rs10487974	11	A	36.9%	SLC13A1	Near	0.02	0.08	0.002	0.02	0.001	0.58	0.001
9	3	rs1878175	54	G	11.2%		Out	0.003	0.003	0.39	0.02	0.003	0.36	0.12
10	3	rs697957	32	T	25.2%	CD47	Near	0.005	0.03	0.03	0.03	0.001	1.65	0.02
11	1	rs952635	9	G	31.3%	PDE4B	In	0.0007	0.009	0.06	0.41	0.001	0.56	0.16
12	3	rs10512839	77	C	25.9%	CPNE4	In	0.02	0.02	0.05	0.009	0.000	1.78	0.03
13	12	rs4767161	84	A	13.3%	RBM19	In	0.19	0.05	0.01	0.002	0.15	0.63	0.0014
14	2	rs1073893	27	A	17.7%	FLJ32745	In	0.008	0.16	0.003	0.06	0.18	0.75	0.0008
15	16	rs10500547	133	G	16.3%	AB051533	In	0.07	0.06	0.03	0.003	0.21	1.29	0.002
16	3	rs1489100	29	G	41.0%		Out	0.01	0.06	0.004	0.16	0.09	0.75	0.0015
17	2	rs2367204	73	G	47.4%	IMMT	In	0.007	0.006	0.27	0.05	0.001	1.58	0.03
18	4	rs10489088	71	C	12.7%		Out	0.24	0.22	0.01	0.001	0.35	1.22	0.005
19	20	rs6093416	86	A	14.0%	TOP1	Near	0.01	0.003	0.22	0.12	0.00	0.35	0.02
20	5	rs871853	14	G	41.5%	CPLX2	In	0.10	0.68	0.001	0.02	0.36	1.15	0.0003
21	7	rs1355037	156	C	23.4%	ZPBP	In	0.29	0.07	0.05	0.001	0.32	1.18	0.006
22	8	rs4418368	82	T	36.1%	DLGAP2	In	0.08	0.08	0.03	0.008	0.27	1.18	0.004
23	4	rs10516471	26	G	43.6%	PPP3CA	In	0.006	0.12	0.02	0.10	0.04	0.70	0.007
24	17	rs2322969	158	C	46.6%		Out	0.18	0.006	0.08	0.02	0.04	1.34	0.003
25	4	rs1395114	28	A	19.3%	BX537758	In	0.004	0.17	0.01	0.22	0.001	1.79	0.02
26	7	rs711517	88	G	18.4%		Out	0.02	0.008	0.26	0.05	0.000	1.86	0.17
27	10	rs332148	80	T	18.5%	WAC	In	0.02	0.01	0.18	0.09	0.004	0.46	0.03
28	16	rs2042389	136	T	32.9%		Out	0.10	0.17	0.07	0.002	0.003	1.54	0.05
29	16	rs7186570	90	G	17.2%	A2BP1	In	0.34	0.12	0.01	0.008	0.91	1.03	0.005
30	8	rs9297181	36	A	19.4%		Out	0.18	0.08	0.004	0.08	0.25	0.79	0.003
31	18	rs540128	85	A	36.2%	PHLPP	In	0.38	0.13	0.02	0.005	0.83	0.97	0.004
32	14	rs1954673	78	A	26.4%		Out	0.005	0.008	0.35	0.43	0.005	0.56	0.63
33	10	rs10509923	154	C	33.0%	CSPG6	Near	0.18	0.002	0.42	0.03	0.008	0.64	0.20
34	5	rs861085	35	T	30.6%	NUDT12	Near	0.008	0.48	0.01	0.28	0.001	0.52	0.02
35	1	rs7531174	33	C	20.6%	SLC44A3	In	0.001	0.21	0.09	0.68	0.001	1.72	0.09
36	7	rs6949530	57	T	18.8%	TAS2R16	Near	0.67	0.83	0.007	0.005	0.96	0.99	0.009
37	5	rs2967017	137	T	45.1%		Out	0.65	0.15	0.06	0.003	0.82	1.04	0.007
38	3	rs729511	159	A	43.8%	SLC9A9	In	0.45	0.003	0.14	0.13	0.03	0.70	0.008
39	9	rs1060586	155	T	49.3%	RBM18	Near	0.16	0.0008	0.67	0.28	0.00	1.60	0.99
40	17	rs2190706	157	T	34.2%		Out	0.48	0.04	0.20	0.007	0.00	1.55	0.03
41	3	rs509208	31	C	16.8%		Out	0.002	0.06	0.64	0.53	0.01	0.51	0.63
42	10	rs7089102	87	G	47.2%		Out	0.04	0.006	0.71	0.49	0.01	1.48	0.86

* Gene symbol and position from UCSC Genome Browser (http://genome.ucsc.edu/; accessed September 2006); SNPs within 60 kb of a known gene are considered 'Near'.

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ISSN: 1471-2350

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