Table 4 Phenotypic Associations With Candidate Genes Previously Related To Stroke, Dementia And Brain MRI Or Cognitive Function Phenotypes: Phenotype-SNP Associations With A GEE Or FBAT P-Value < 0.001
Gene | Phenotype | SNP | Chr | Physical Position | GEE_Pvalue | FBAT_Pvalue |
|---|---|---|---|---|---|---|
NGFB | AHPV | rs10489531 | 1 | 115495044 | 9.7 × 10-4 | 0.046 |
PRSS25 | ATBV | rs363685 | 2 | 74726491 | 2.5 × 10-4 |  |
|  | ATCBV | rs363685 | 2 | 74726491 | 5.7 × 10-5 |  |
GRK4 | F1 | rs2105380 | 4 | 3019934 | 0.276 | 5.8 × 10-4 |
HMGE | ATBV | rs4689584 | 4 | 7179291 | 0.035 | 1.0 × 10-4 |
APBB2 | F1 | rs10517001 | 4 | 41051593 | 1.4 × 10-4 | 0.009 |
SNCA | Sim | rs3796661 | 4 | 91044685 | 2.6 × 10-4 | 0.332 |
|  | AHPV | rs2870028 | 4 | 91122391 | 3.2 × 10-4 | 0.180 |
|  | AHPV | rs7678651 | 4 | 91125549 | 1.3 × 10-4 | 0.102 |
|  | AHPV | rs10516848 | 4 | 91132390 | 1.6 × 10-4 | 0.115 |
PDE4D | WRAT | rs295973 | 5 | 58945866 | 5.3 × 10-4 | 0.060 |
|  | Sim | rs10514882 | 5 | 59170282 | 6.4 × 10-5 |  |
|  | Sim | rs9292216 | 5 | 59187886 | 2.4 × 10-4 |  |
DCDC2 | F3 | rs10484657 | 6 | 24224829 | 0.017 | 9.5 × 10-4 |
|  | ATCBV | rs10484657 | 6 | 24224829 | 6.0 × 10-4 | 0.015 |
THBS2 | ATBV | rs6937001 | 6 | 169382718 | 6.0 × 10-4 | 0.021 |
GATA4 | WRAT | rs7006733 | 8 | 11645399 | 0.034 | 3.1 × 10-4 |
NRG1 | ATCBV | rs1383893 | 8 | 31844190 | 0.407 | 8.9 × 10-4 |
|  | F2 | rs10503906 | 8 | 32291504 | 0.187 | 4.2 × 10-4 |
|  | AFBV | rs10503919 | 8 | 32519284 | 1.9 × 10-4 | 0.288 |
|  | BMRIZLWMH | rs10503926 | 8 | 32660758 | 8.7 × 10-5 | 0.009 |
|  | VMV | rs10503927 | 8 | 32662772 | 2.0 × 10-4 | 0.002 |
VLDLR | ATCBV | rs502309 | 9 | 2562909 | 5.4 × 10-6 | 0.157 |
|  | Nam | rs2168136 | 9 | 2584577 | 1.6 × 10-4 | 0.006 |
NTRK2 | F1 | rs10512152 | 9 | 84457363 | 7.6 × 10-5 | 0.018 |
|  | AFBV | rs1573219 | 9 | 84617176 | 0.174 | 5.6 × 10-4 |
|  | AFBV | rs7038866 | 9 | 84617461 | 0.146 | 3.6 × 10-4 |
TEK | ATBV | rs628873 | 9 | 27162838 | 4.9 × 10-4 | 0.051 |
BACE1 | APBV | rs1261791 | 11 | 116705848 | 0.021 | 3.1 × 10-4 |
SORL1 | Sim | rs1131497 | 11 | 121007955 | 0.008 | 3.2 × 10-6 |
|  | Sim | rs726601 | 11 | 120986617 | 0.046 | 8.2 × 10-4 |
VWF | ATCBV | rs216903 | 12 | 5975760 | 0.149 | 9.5 × 10-4 |
A2M | F3 | rs2889717 | 12 | 9178068 | 9.3 × 10-5 |  |
LRRK2 | WRAT | rs2249017 | 12 | 38847487 | 5.5 × 10-4 | 0.061 |
|  | F1 | rs7975693 | 12 | 38874945 | 8.1 × 10-5 | 0.005 |
|  | AFBV | rs10506151 | 12 | 38957265 | 3.7 × 10-4 | 1.6 × 10-4 |
|  | ATBV | rs10506151 | 12 | 38957265 | 9.7 × 10-4 | 0.371 |
CNTN1 | ATBV | rs10506176 | 12 | 39561067 | 8.8 × 10-4 | 0.622 |
LTA4H | Sim | rs10492226 | 12 | 94906457 | 6.7 × 10-4 |  |
IGF1 | ALLV | rs1980236 | 12 | 101270359 | 0.046 | 9.3 × 10-4 |
LTB4R2 | APBV | rs724165 | 14 | 23876069 | 4.5 × 10-4 | 0.162 |
NTRK3 | ALLV | rs10520671 | 15 | 86347520 | 6.2 × 10-5 | 0.062 |
CCL2 | WRAT | rs1024612 | 17 | 29573469 | 0.231 | 7.0 × 10-4 |
PRKCA | F1 | rs9303511 | 17 | 62158093 | 0.068 | 7.9 × 10-4 |
CST3 | AOBV | rs1158167 | 20 | 23526189 | 6.5 × 10-4 | 0.032 |
PRNP | APBV | rs2326510 | 20 | 4649211 | 0.000718 | 0.064794 |
BACE2 | F1 | rs2007397 | 21 | 41438062 | 0.030 | 2.2 × 10-4 |
|  | F1 | rs10483073 | 21 | 41499167 | 3.5 × 10-4 |  |
|  | Nam | rs10483073 | 21 | 41499167 | 1.7 × 10-4 |  |