2, section a: GEE, Top 25 p-values | ||||||
---|---|---|---|---|---|---|
Phenotype | SNP | Chromosome | Physical location | GEE p-value | FBAT p-value | Gene Region (within 60 kb) |
ATCBV | rs1970546 | 20 | 59287333 | 4.0 × 10-8 | 0.005 | CDH4 |
F3 | rs2179965* | 1 | 88514033 | 1.1 × 10-6 | 0.013 |  |
Nam | rs1155865 | 4 | 67562623 | 1.6 × 10-6 | 0.554 |  |
F3 | rs2832077 | 21 | 29062892 | 1.8 × 10-6 | 0.007 |  |
F2 | rs2352904 | 14 | 48442551 | 2.1 × 10-6 | 0.012 |  |
F2 | rs6914079* | 6 | 14704344 | 2.2 × 10-6 | 0.018 |  |
F2 | rs9325032 | 5 | 146395409 | 2.8 × 10-6 | 0.008 |  |
ALLV | rs2847476 | 11 | 113696226 | 3.0 × 10-6 | 0.001 | NNMT |
Sim | rs3891355 | 12 | 105453162 | 3.2 × 10-6 | 0.089 | POLR3B, RFX4 |
ATBV | rs5028798 | 11 | 34562011 | 3.3 × 10-6 | 0.394 | EHF |
Nam | rs530965 | 11 | 78742749 | 3.5 × 10-6 | 0.119 |  |
Nam | rs9303401 | 17 | 54202944 | 4.9 × 10-6 | 0.099 | PPM1E |
AFBV | rs952700 | 11 | 99090946 | 5.7 × 10-6 | 0.003 | CNTN5 |
F3 | rs1031381 | 11 | 133593892 | 6.0 × 10-6 | 0.075 | NCAPD3 |
F2 | rs10489896* | 1 | 230890353 | 6.2 × 10-6 | 0.109 | TARBP1 |
WRAT | rs9300212 | 12 | 33592433 | 8.2 × 10-6 | 0.002 |  |
Nam | rs1831521 | 9 | 90488911 | 8.4 × 10-6 | 0.002 | DIRAS2 |
F3 | rs934299 | 2 | 137172672 | 9.0 × 10-6 | 0.318 |  |
ALTHBV | rs360929 | 4 | 153265305 | 9.1 × 10-6 | 0.055 |  |
F2 | rs2893363 | 7 | 29952294 | 9.6 × 10-6 | 0.812 | C7orf41 |
WRAT | rs10502991 | 18 | 50243287 | 1.0 × 10-5 | 0.001 |  |
APBV | rs2769965 | 9 | 79048598 | 1.1 × 10-5 | 0.012 |  |
APBV | rs719435 | 7 | 31324796 | 1.1 × 10-5 | 0.188 | CCDC129 |
F1 | rs9292769 | 5 | 40433668 | 1.1 × 10-5 | 0.163 |  |
Nam | rs10506718 | 12 | 75377929 | 1.1 × 10-5 | 0.402 |  |
2, section b: FBAT, Top 25 p-values | ||||||
Trait | SNP | Chromosome | Physical location | GEE p-value | FBAT p-value | Gene Region(s) (within 60 kb) |
ALLV | rs7124781 | 11 | 42513374 | 0.008 | 2.0 × 10-7 |  |
Sim | rs1131497 | 11 | 121007955 | 0.008 | 3.2 × 10-6 | SORL1 |
WRAT | rs10506065 | 12 | 30342307 | 0.050 | 5.0 × 10-6 |  |
AFBV | rs3852286 | 7 | 140126618 | 0.145 | 6.5 × 10-6 | BRAF and MRPS33 |
WRAT | rs4529807 | 10 | 22358107 | 0.013 | 1.1 × 10-5 | DNAJC1 |
F3 | rs847342 | 14 | 71805791 | 0.441 | 1.3 × 10-5 | RGS6 |
AFBV | rs719775 | 3 | 64366493 | 0.001 | 1.8 × 10-5 |  |
Sim | rs936111 | 15 | 99376659 | 0.014 | 2.1 × 10-5 | LRRK1 |
ATBV | rs2143881 | 6 | 50960846 | 0.077 | 2.1 × 10-5 | TFAP2B |
AHPV | rs9293140 | 5 | 24643203 | 0.092 | 2.1 × 10-5 | CDH10 |
AFBV | rs9288446* | 2 | 212907533 | 0.001 | 2.3 × 10-5 | ERBB4 |
APBV | rs1472962 | 4 | 95949555 | 0.004 | 3.1 × 10-5 | PDLIM5 |
ATBV | rs2793772 | 13 | 99029574 | 0.047 | 3.3 × 10-5 | CLYBL |
F2 | rs1333583 | 13 | 82037151 | 0.031 | 3.4 × 10-5 |  |
ATBV | rs10497352 | 2 | 170781278 | 0.005 | 3.6 × 10-5 | ZNF650 |
F1 | rs497836 | 13 | 93605509 | 0.020 | 3.8 × 10-5 | GPC6 |
APBV | rs6459928 | 7 | 158428045 | 0.271 | 4.0 × 10-5 | VIPR2 |
AHPV | rs1963442 | 3 | 75872661 | 0.046 | 4.3 × 10-5 | ZNF717 |
APBV | rs10503238 | 8 | 4027465 | 0.002 | 4.4 × 10-5 |  |
F2 | rs2861215 | 2 | 77958447 | 0.006 | 4.7 × 10-5 |  |
Nam | rs9311168 | 3 | 37952421 | 0.067 | 4.9 × 10-5 | CTDSPL |
F2 | rs2029395 | 2 | 1.8 × 10-8 | 0.027 | 4.9 × 10-5 | TTN, FLJ39502 |
ATCBV | rs10510717 | 3 | 41307494 | 0.005 | 5.0 × 10-5 | CTNNB1 |
ATBV | rs1433527 | 2 | 1.8 × 10-8 | 0.028 | 5.1 × 10-5 | DDX18 |
2, section c: Linkage Peaks with LOD scores ≥ 2.0. | ||||||
Trait | SNP closest to linkage peak | Chromosome | Physical location | 1.5 – LOD support interval start | 1.5 – LOD support interval end | LOD score |
WATBV†| rs1547275 | 9 | 79548023 | 76128637 | 86702472 | 2.81 |
WF3†| rs2975420 | 8 | 19534278 | 12651557 | 22836499 | 2.20 |
WNam†| rs2765241 | 1 | 62439617 | 59085658 | 67006164 | 2.95 |
WNam†| rs293966 | 11 | 26536069 | 21237681 | 33363547 | 2.14 |
WWRAT†| rs10512187 | 9 | 87400439 | 84893406 | 110115339 | 2.04 |
WWRAT†| rs1328822 | 13 | 93605666 | 87815515 | 97536766 | 2.50 |
WWRAT†| rs1846090 | 18 | 14573728 | 13423610 | 19583575 | 5.10 |
WWRAT†| rs10518241 | 19 | 3540074 | 1888178 | 6189414 | 2.33 |
BMRIZLWMHVMV | rs4426714 | 4 | 5052671 | 105905 | 9505355 | 2.20 |
BMRIZLWMHVMV | rs236535 | 17 | 65788911 | 59677087 | 68475624 | 2.09 |