|  |  | Exam cycle |  | |
---|---|---|---|---|---|
Phenotypic Trait (Abbreviated Variable Name) | Number of traits | N | Original Cohort (Exam 26) | Offspring Cohort (Exam 7) | Covariates Used to Create Multivariable-Adjusted Residuals |
Volumetric Brain MRI* | |||||
Total Cerebral Brain Volume (ATCBV) | 1 | 705 | Original Cohort & Offspring data are pooled | Age, age-squared, sex, current smoking status, diabetes, systolic blood pressure, anti-hypertensive drugs, atrial fibrillation, EKG-LVH at Offspring examination 7 and Original cohort 26; data from sex-specific regressions pooled. | |
Frontal Brain volume (AFBV) | 1 | 705 | Â | Â | Â |
Parietal Brain Volume (APBV) | 1 | 705 | Â | Â | Â |
Occipital Brain Volume (AOBV) | 1 | 705 | Â | Â | Â |
Temporal Brain volume (ATBV) | 1 | 705 | Â | Â | Â |
Hippocampal Volume (AHPV) | 1 | 327 | Â | Â | Â |
Lateral Ventricular Volume (ALVV)†| 1 | 705 |  |  |  |
Temporal Horn Volume (LTHBV)†| 1 | 705 |  |  |  |
White Matter Hyperintensity Volume (BMRIZLWMHVMV) [Age-, sex-specific Z-score of log-normalized white matter hyperintensity volume] | 1 | 705 | Â | Â | Current smoking status, diabetes, systolic blood pressure, anti-hypertensive drugs, atrial fibrillation, EKG-LVH at Offspring examination 7 and Original cohort 26; data from sex-specific regressions pooled. |
Cognitive Test Performance | |||||
Factor 1:Verbal Memory (F1) | 1 | 694 | Original cohort and Offspring data are pooled | Birth cohort by decade, education, Framingham Stroke Risk Profile score, plasma homocysteine concentrations (at the 20th Original cohort and the 6th Offspring examinations), apolipoprotein E genotype (ε4 +ve/-ve); data from sex-specific regressions were pooled. | |
Factor 2:Visual Memory and Organization (F2) | 1 | 694 | Â | Â | Â |
Factor 3: Measure of attention and executive function-Trails A and B (F3) | 1 | 694 | Â | Â | Â |
Boston Naming Test (Nam) | 1 | 694 | Â | Â | Â |
Similarities (Sim) | 1 | 694 | Â | Â | Â |
Wide-Range Achievement Test (WRAT) | 1 | 694 | Â | Â | Â |