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Table 1 Phenotypes included in the study

From: Genome-wide association with bone mass and geometry in the Framingham Heart Study

Trait Abbreviation Gender (N) Cohort, exam cycle Adjustment*
Bone mineral density (BMD)     
Femoral BMD** FNBMD Combined (1141) Original, ex. 22–24, Offspring, ex. 6–7 1) multivariable-adjusted residuals (age, age2, height, BMI, smoking, physical activity, estrogen therapy)
  FNBMDf Females (646)   
  FNBMDm Males (495)   
Trochanter BMD** TRBMD Same as above Same as above Same as above
  TRBMDf    
  TRBMDm    
Lumbar spine BMD** LSBMD Combined (1117) Same as above Same as above
  LSBMDf Females (641)   
  LSBMDm Males (486)   
Quantitative ultrasound (QUS)     
Broadband ultrasound attenuation** BUA Combined (1105) Original, ex. 24, Offspring, ex. 6–7 1) multivariable-adjusted residuals (age, age2, height, BMI, smoking, physical activity, estrogen therapy)
Speed of Sound SOS Combined (1104) Same as above Same as above
Hip geometry     
Neck-shaft angle** NSA1 Combined (1096) Original, ex. 22–24, Offspring, ex. 6–7 1) age, age2
2) multivariable-adjusted ranked residuals (age, age2, height, BMI)
  NSAf Females (622)   
  NSAm Males (474)   
Femoral neck length** NeckLeng1 Combined (1090) Same as above Same as above
  NeckLengf Females (619)   
  NeckLengm Males (471)   
Neck width** NeckW1r Combined (1095) Same as above Same as above
  NeckW1rf Females (618)   
  NeckW1rm Males (477)   
Neck section modulus** NeckZ1r Combined (1096) Same as above Same as above
  NeckZ1rf Females (618)   
  NeckZ1rm Males (478)   
Neck Cross-Sectional Moment of Inertia NeckCSMI1r Combined (1094) Same as above Same as above
  NeckCSMI1rf Females (618)   
  NeckCSMI1rm Males (476)   
Neck Average Buckling Ratio NeckAvgBR1r Combined (1096) Same as above Same as above
  NeckAvgBR1rf Females (618)   
  NeckAvgBR1rm Males (478)   
Shaft width** ShaftW1 Combined (1028) Same as above Same as above
  ShaftW1f Females (599)   
  ShaftW1m Males (429)   
Shaft Section modulus** ShaftZ1r Combined (1028) Same as above Same as above
  ShaftZ1rf Females (599)   
  ShaftZ1rm Males (429)   
Shaft Cross-Sectional Moment of Inertia ShaftCSMIr Combined (1026) Same as above Same as above
  ShaftCSMIrf Females (599)   
  ShaftCSMIrm Males (427)   
Shaft Average Buckling Ratio ShaftAvgBR1r Combined (1028) Same as above Same as above
  ShaftAvgBR1rf Females (599)   
  ShaftAvgBR1rm Males (429)   
Inter-Trochanteric Average Buckling Ratio ITAvgBR1r Combined (1024) Same as above Same as above
  ITAvgBR1rf Females (596)   
  ITAvgBR1rm Males (428)   
  1. *adjustment performed in each Cohort (generation) and gender
  2. **primary traits reported here