Genome-wide association with bone mass and geometry in the Framingham Heart Study

Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David

doi:10.1186/1471-2350-8-S1-S14

BMC Medical Genetics

Table 1 Phenotypes included in the study

From: Genome-wide association with bone mass and geometry in the Framingham Heart Study

Trait	Abbreviation	Gender (N)	Cohort, exam cycle	Adjustment*
Bone mineral density (BMD)
Femoral BMD**	FNBMD	Combined (1141)	Original, ex. 22–24, Offspring, ex. 6–7	1) multivariable-adjusted residuals (age, age², height, BMI, smoking, physical activity, estrogen therapy)
	FNBMDf	Females (646)
	FNBMDm	Males (495)
Trochanter BMD**	TRBMD	Same as above	Same as above	Same as above
	TRBMDf
	TRBMDm
Lumbar spine BMD**	LSBMD	Combined (1117)	Same as above	Same as above
	LSBMDf	Females (641)
	LSBMDm	Males (486)
Quantitative ultrasound (QUS)
Broadband ultrasound attenuation**	BUA	Combined (1105)	Original, ex. 24, Offspring, ex. 6–7	1) multivariable-adjusted residuals (age, age², height, BMI, smoking, physical activity, estrogen therapy)
Speed of Sound	SOS	Combined (1104)	Same as above	Same as above
Hip geometry
Neck-shaft angle**	NSA1	Combined (1096)	Original, ex. 22–24, Offspring, ex. 6–7	1) age, age² 2) multivariable-adjusted ranked residuals (age, age², height, BMI)
	NSAf	Females (622)
	NSAm	Males (474)
Femoral neck length**	NeckLeng1	Combined (1090)	Same as above	Same as above
	NeckLengf	Females (619)
	NeckLengm	Males (471)
Neck width**	NeckW1r	Combined (1095)	Same as above	Same as above
	NeckW1rf	Females (618)
	NeckW1rm	Males (477)
Neck section modulus**	NeckZ1r	Combined (1096)	Same as above	Same as above
	NeckZ1rf	Females (618)
	NeckZ1rm	Males (478)
Neck Cross-Sectional Moment of Inertia	NeckCSMI1r	Combined (1094)	Same as above	Same as above
	NeckCSMI1rf	Females (618)
	NeckCSMI1rm	Males (476)
Neck Average Buckling Ratio	NeckAvgBR1r	Combined (1096)	Same as above	Same as above
	NeckAvgBR1rf	Females (618)
	NeckAvgBR1rm	Males (478)
Shaft width**	ShaftW1	Combined (1028)	Same as above	Same as above
	ShaftW1f	Females (599)
	ShaftW1m	Males (429)
Shaft Section modulus**	ShaftZ1r	Combined (1028)	Same as above	Same as above
	ShaftZ1rf	Females (599)
	ShaftZ1rm	Males (429)
Shaft Cross-Sectional Moment of Inertia	ShaftCSMIr	Combined (1026)	Same as above	Same as above
	ShaftCSMIrf	Females (599)
	ShaftCSMIrm	Males (427)
Shaft Average Buckling Ratio	ShaftAvgBR1r	Combined (1028)	Same as above	Same as above
	ShaftAvgBR1rf	Females (599)
	ShaftAvgBR1rm	Males (429)
Inter-Trochanteric Average Buckling Ratio	ITAvgBR1r	Combined (1024)	Same as above	Same as above
	ITAvgBR1rf	Females (596)
	ITAvgBR1rm	Males (428)

*adjustment performed in each Cohort (generation) and gender
**primary traits reported here

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ISSN: 1471-2350

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