Table 1 Phenotypes included in the study
From: Genome-wide association with bone mass and geometry in the Framingham Heart Study
| Trait | Abbreviation | Gender (N) | Cohort, exam cycle | Adjustment* |
|---|---|---|---|---|
| Bone mineral density (BMD) | ||||
| Femoral BMD** | FNBMD | Combined (1141) | Original, ex. 22–24, Offspring, ex. 6–7 | 1) multivariable-adjusted residuals (age, age2, height, BMI, smoking, physical activity, estrogen therapy) |
| FNBMDf | Females (646) | |||
| FNBMDm | Males (495) | |||
| Trochanter BMD** | TRBMD | Same as above | Same as above | Same as above |
| TRBMDf | ||||
| TRBMDm | ||||
| Lumbar spine BMD** | LSBMD | Combined (1117) | Same as above | Same as above |
| LSBMDf | Females (641) | |||
| LSBMDm | Males (486) | |||
| Quantitative ultrasound (QUS) | ||||
| Broadband ultrasound attenuation** | BUA | Combined (1105) | Original, ex. 24, Offspring, ex. 6–7 | 1) multivariable-adjusted residuals (age, age2, height, BMI, smoking, physical activity, estrogen therapy) |
| Speed of Sound | SOS | Combined (1104) | Same as above | Same as above |
| Hip geometry | ||||
| Neck-shaft angle** | NSA1 | Combined (1096) | Original, ex. 22–24, Offspring, ex. 6–7 |
1) age, age2 2) multivariable-adjusted ranked residuals (age, age2, height, BMI) |
| NSAf | Females (622) | |||
| NSAm | Males (474) | |||
| Femoral neck length** | NeckLeng1 | Combined (1090) | Same as above | Same as above |
| NeckLengf | Females (619) | |||
| NeckLengm | Males (471) | |||
| Neck width** | NeckW1r | Combined (1095) | Same as above | Same as above |
| NeckW1rf | Females (618) | |||
| NeckW1rm | Males (477) | |||
| Neck section modulus** | NeckZ1r | Combined (1096) | Same as above | Same as above |
| NeckZ1rf | Females (618) | |||
| NeckZ1rm | Males (478) | |||
| Neck Cross-Sectional Moment of Inertia | NeckCSMI1r | Combined (1094) | Same as above | Same as above |
| NeckCSMI1rf | Females (618) | |||
| NeckCSMI1rm | Males (476) | |||
| Neck Average Buckling Ratio | NeckAvgBR1r | Combined (1096) | Same as above | Same as above |
| NeckAvgBR1rf | Females (618) | |||
| NeckAvgBR1rm | Males (478) | |||
| Shaft width** | ShaftW1 | Combined (1028) | Same as above | Same as above |
| ShaftW1f | Females (599) | |||
| ShaftW1m | Males (429) | |||
| Shaft Section modulus** | ShaftZ1r | Combined (1028) | Same as above | Same as above |
| ShaftZ1rf | Females (599) | |||
| ShaftZ1rm | Males (429) | |||
| Shaft Cross-Sectional Moment of Inertia | ShaftCSMIr | Combined (1026) | Same as above | Same as above |
| ShaftCSMIrf | Females (599) | |||
| ShaftCSMIrm | Males (427) | |||
| Shaft Average Buckling Ratio | ShaftAvgBR1r | Combined (1028) | Same as above | Same as above |
| ShaftAvgBR1rf | Females (599) | |||
| ShaftAvgBR1rm | Males (429) | |||
| Inter-Trochanteric Average Buckling Ratio | ITAvgBR1r | Combined (1024) | Same as above | Same as above |
| ITAvgBR1rf | Females (596) | |||
| ITAvgBR1rm | Males (428) |