Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Lunetta, Kathryn L; D'Agostino, Ralph B; Karasik, David; Benjamin, Emelia J; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas P; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M

doi:10.1186/1471-2350-8-S1-S13

Table 4 All Significant SNP Associations with Selected Longevity Candidate Genes* (FBAT or GEE p-value < 0.01)

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Trait	Gene	SNP	Chr	Physical Position	FBAT p-value	GEE p-value	SNP function	SNP position relative to gene (up to 60 kb)
Age at death	FOXO1a	rs4943794	13	40,071,408	0.068	0.00028	Intron	in
		rs10507486	13	40,084,501	0.043	0.00013	Intron	in
	GAPDH†	rs4764600	12	6,472,241	0.833	0.005	Locus/intron	near
	KL	rs683907	13	32,522,175	0.009	0.507	Intron	in
		rs687045	13	32,522,889	0.007	0.712	Intron	in
	LEPR	rs1475398	1	65,695,278	0.069	0.005	Untranslated	in
		rs1343981	1	65,757,349	0.031	0.006	Intron	in
		rs10493379	1	65,757,948	0.015	0.004	Intron	in
		rs2154380	1	65,769,462	0.004	0.003	Intron	in
		rs6669117	1	65,773,093	0.050	0.007	Intron	in
	PON1	rs2374983	7	94,516,375	0.980	0.006	Intron	near
	PSEN1	rs362356	14	72,708,382	0.005	0.130	Intron	in
	SOD2	rs911847	6	160,039,379	0.358	0.005	Unknown	near
	WRN‡	rs2543600	8	30,969,282	0.182	4.2 × 10 ^-6	Unknown	near
Morbidity-free survival at age 65	GHR	rs719756	5	42,761,386	0.003	0.676	Unknown	near
	LEPR	rs1171278	1	65,700,167	0.042	0.003	Untranslated	in
		rs3790426	1	65,755,040	0.460	0.002	Intron	in
	MORF4L1	rs1383636	15	76,893,275	0.458	0.007	Unknown	near
	PON1	rs2374983	7	94,516,375	0.727	0.007	Intron	near
		rs854523	7	94,542,884	0.850	0.007	Intron	in
	PTH	rs10500784	11	13,530,401	0.010	0.990	Unknown	near
	WRN‡	rs2725369	8	30,970,566	0.113	0.003	Unknown	near
Biologic Age by OSS	FOXO1a	rs1923249	13	40,041,881	0.006	0.004	Intron	in
		rs4943794	13	40,071,408	0.009	0.016	Intron	in
	HSPA9	rs256014	5	137,930,983	0.101	0.005	Intron	in
	LASS6	rs1002666	2	169,303,525	0.001	0.008	Intron	in
	SOD2	rs911847	6	160,039,379	0.024	0.009	Unknown	near
	TLR4	rs1927914	9	117,544,279	0.007	0.401	Locus	near
Walking speed	ESR1	rs9322361	6	152,551,257	0.124	0.0089	Intron	in
	LASS6	rs6433083	2	169,324,821	0.232	0.006	Intron	in
	NR3C1	rs2918418	5	142,703,566	0.005	0.081	Intron	in
		rs10515522	5	142,738,587	0.004	0.084	Intron	in
	SOD1	rs2833485	21	32,000,796	0.008	0.507	Locus/intron	in
	TERF2	rs728546	16	68,013,029	0.0045	0.533	Unknown	near
	FASLG	rs6700734	1	169,362,468	0.003	0.029	Intron	in

*79 genes identified from NCBI, SAGE ke, and GenAge databases; 12 genes with no SNPs on 100K chip; 67 genes with 1–45 SNPs on 100K chip; LGV1 2036 SNPs on 100K chip, results for this region available on the web
†The most strongly associated SNP near GAPDH is actually closer to MRPL51
‡The most strongly associated SNP near WRN is actually closer to PURG

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ISSN: 1471-2350

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