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Table 4 All Significant SNP Associations with Selected Longevity Candidate Genes* (FBAT or GEE p-value < 0.01)

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Trait Gene SNP Chr Physical Position FBAT p-value GEE p-value SNP function SNP position relative
to gene (up to 60 kb)
Age at death FOXO1a rs4943794 13 40,071,408 0.068 0.00028 Intron in
   rs10507486 13 40,084,501 0.043 0.00013 Intron in
  GAPDH† rs4764600 12 6,472,241 0.833 0.005 Locus/intron near
  KL rs683907 13 32,522,175 0.009 0.507 Intron in
   rs687045 13 32,522,889 0.007 0.712 Intron in
  LEPR rs1475398 1 65,695,278 0.069 0.005 Untranslated in
   rs1343981 1 65,757,349 0.031 0.006 Intron in
   rs10493379 1 65,757,948 0.015 0.004 Intron in
   rs2154380 1 65,769,462 0.004 0.003 Intron in
   rs6669117 1 65,773,093 0.050 0.007 Intron in
  PON1 rs2374983 7 94,516,375 0.980 0.006 Intron near
  PSEN1 rs362356 14 72,708,382 0.005 0.130 Intron in
  SOD2 rs911847 6 160,039,379 0.358 0.005 Unknown near
  WRN‡ rs2543600 8 30,969,282 0.182 4.2 × 10 -6 Unknown near
Morbidity-free survival at age 65 GHR rs719756 5 42,761,386 0.003 0.676 Unknown near
  LEPR rs1171278 1 65,700,167 0.042 0.003 Untranslated in
   rs3790426 1 65,755,040 0.460 0.002 Intron in
  MORF4L1 rs1383636 15 76,893,275 0.458 0.007 Unknown near
  PON1 rs2374983 7 94,516,375 0.727 0.007 Intron near
   rs854523 7 94,542,884 0.850 0.007 Intron in
  PTH rs10500784 11 13,530,401 0.010 0.990 Unknown near
  WRN‡ rs2725369 8 30,970,566 0.113 0.003 Unknown near
Biologic Age by OSS FOXO1a rs1923249 13 40,041,881 0.006 0.004 Intron in
   rs4943794 13 40,071,408 0.009 0.016 Intron in
  HSPA9 rs256014 5 137,930,983 0.101 0.005 Intron in
  LASS6 rs1002666 2 169,303,525 0.001 0.008 Intron in
  SOD2 rs911847 6 160,039,379 0.024 0.009 Unknown near
  TLR4 rs1927914 9 117,544,279 0.007 0.401 Locus near
Walking speed ESR1 rs9322361 6 152,551,257 0.124 0.0089 Intron in
  LASS6 rs6433083 2 169,324,821 0.232 0.006 Intron in
  NR3C1 rs2918418 5 142,703,566 0.005 0.081 Intron in
   rs10515522 5 142,738,587 0.004 0.084 Intron in
  SOD1 rs2833485 21 32,000,796 0.008 0.507 Locus/intron in
  TERF2 rs728546 16 68,013,029 0.0045 0.533 Unknown near
  FASLG rs6700734 1 169,362,468 0.003 0.029 Intron in
  1. *79 genes identified from NCBI, SAGE ke, and GenAge databases; 12 genes with no SNPs on 100K chip; 67 genes with 1–45 SNPs on 100K chip; LGV1 2036 SNPs on 100K chip, results for this region available on the web
  2. †The most strongly associated SNP near GAPDH is actually closer to MRPL51
  3. ‡The most strongly associated SNP near WRN is actually closer to PURG
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