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Table 3 All Significant SNP Associations (GEE or FBAT p-value < 0.01) for at least Two Traits

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

3a. FBAT: Age at Death and Morbidity-Free Survival at 65 years
Trait 1 Trait 2 SNP Chr Physical Position Gene Trait 1 GEE p-value Trait 1 FBAT p-value Trait 2 GEE p-value Trait 2 FBAT p-value
Age at Death Morbidity-free at 65 rs6682403 1 234,743,324   0.849 0.004 0.106 0.004
   rs10488907 4 113,669,709 ALPK1 0.452 0.008 0.336 0.009
   rs17190837 9 13,391,548   0.010 0.009 0.097 0.004
   rs4752977 11 47,257,005 MADD 0.736 0.008 0.002 0.009
   rs10506274 12 80,103,932   0.531 0.001 0.989 0.001
   rs2831154 21 28,059,331   0.323 0.008 0.358 0.006
   rs243725* 21 28,060,803   0.264 0.007 0.359 0.008
*r2 > 0.80 with the preceding SNP
3b. GEE: Age at Death and Morbidity-Free Survival at 65 years
Trait 1 Trait 2 SNP Chr Physical Position Gene Trait 1 GEE p-value Trait 1 FBAT p-value Trait 2 GEE p-value Trait 2 FBAT p-value
Age at Death Morbidity-free at 65 rs9308261 1 113,603,160 MAGI3 0.009 0.156 0.002 0.900
   rs10490518 2 31,223,004 GALNT14 0.009 0.373 0.010 0.948
   rs2374983 7 94,516,375 PPP1R9A/PON1 0.006 0.980 0.007 0.727
   rs655883 11 98,994,584 CNTN5 0.006 0.390 0.001 0.293
   rs1368850 11 130,433,518   0.004 0.387 0.005 0.292
   rs4943116 13 32,995,650 STARD13 0.006 0.205 0.008 0.049
   rs2254191 13 45,344,403   0.007 0.425 0.004 0.116
   rs1620210 13 45,759,488 C13orf18 0.001 0.161 0.004 0.068
   rs2823322 21 15,814,903   0.0004 0.045 0.006 0.029
3c. FBAT: Biologic Age and Walking Speed
Trait 1 Trait 2 SNP Chr Physical Position Gene Trait 1 GEE p-value Trait 1 FBAT p-value Trait 2 GEE p-value Trait 2 FBAT p-value
Biologic age Walking speed rs873348 4 178,246,509   0.135 0.004 0.114 0.006
Biologic age Walking speed rs10520361* 4 178,247,037   0.074 0.006 0.054 0.005
Biologic age Walking speed rs31564 5 135,258,152 IL9 0.015 0.001 0.008 0.002
Biologic age Walking speed rs1862345 5 148,018,498 HTR4 0.172 0.0002 0.399 0.008
Biologic age Walking speed rs7844834 8 11,323,556 C8orf12|C8orf13 0.017 0.004 0.011 0.004
Biologic age Walking speed rs952658 12 20,756,568 SLCO1C1 0.024 0.008 0.935 0.006
Biologic age Walking speed rs6487366 12 23,994,617 SOX5 0.017 0.003 0.959 0.004
Biologic age Walking speed rs7135493 12 28,134,847   0.020 0.006 0.033 0.004
Biologic age Walking speed rs10492036 12 124,728,934   0.308 0.005 0.169 0.009
Biologic age Walking speed rs1978945 13 105,641,257   0.093 0.009 0.031 0.006
Biologic age Walking speed rs2165723* 13 105,641,610   0.046 0.010 0.027 0.003
Biologic age Walking speed rs10492651* 13 105,641,634   0.083 0.009 0.023 0.001
Biologic age Walking speed rs9301112* 13 105,642,018   0.097 0.004 0.053 0.003
* r2 > 0.8 with the preceding SNP (calculated if the distance is <250,000 base pairs)
3d. GEE: Biologic Age and Walking Speed
Trait 1 Trait 2 SNP Chr Physical Position Gene Trait 1 GEE p-value Trait 1 FBAT p-value Trait 2 GEE p-value Trait 2 FBAT p-value
Biologic Age Walking speed rs1474827 6 134,886,011   0.007 0.746 0.000 0.233
Biologic Age Walking speed rs10231641 7 119,166,342   0.004 0.077 0.009 0.278
Biologic Age Walking speed rs310575 8 51,603,257 SNTG1 0.008 0.209 0.003 0.007
Biologic Age Walking speed rs10520603 15 84,170,955   0.009 0.008 0.003 0.050
Biologic Age Walking speed rs7166323* 15 84,171,745   0.009 0.012 0.003 0.065
Biologic Age Walking speed rs2215921 16 9,604,834   0.007 0.049 0.001 0.316
* r2 > 0.8 with the preceding SNP (calculated if the distance is <250,000 base pairs)
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