Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Lunetta, Kathryn L; D'Agostino, Ralph B; Karasik, David; Benjamin, Emelia J; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas P; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M

doi:10.1186/1471-2350-8-S1-S13

Table 3 All Significant SNP Associations (GEE or FBAT p-value < 0.01) for at least Two Traits

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

3a. FBAT: Age at Death and Morbidity-Free Survival at 65 years
Trait 1	Trait 2	SNP	Chr	Physical Position	Gene	Trait 1 GEE p-value	Trait 1 FBAT p-value	Trait 2 GEE p-value	Trait 2 FBAT p-value
Age at Death	Morbidity-free at 65	rs6682403	1	234,743,324		0.849	0.004	0.106	0.004
		rs10488907	4	113,669,709	ALPK1	0.452	0.008	0.336	0.009
		rs17190837	9	13,391,548		0.010	0.009	0.097	0.004
		rs4752977	11	47,257,005	MADD	0.736	0.008	0.002	0.009
		rs10506274	12	80,103,932		0.531	0.001	0.989	0.001
		rs2831154	21	28,059,331		0.323	0.008	0.358	0.006
		rs243725*	21	28,060,803		0.264	0.007	0.359	0.008
*r² > 0.80 with the preceding SNP
3b. GEE: Age at Death and Morbidity-Free Survival at 65 years
Trait 1	Trait 2	SNP	Chr	Physical Position	Gene	Trait 1 GEE p-value	Trait 1 FBAT p-value	Trait 2 GEE p-value	Trait 2 FBAT p-value
Age at Death	Morbidity-free at 65	rs9308261	1	113,603,160	MAGI3	0.009	0.156	0.002	0.900
		rs10490518	2	31,223,004	GALNT14	0.009	0.373	0.010	0.948
		rs2374983	7	94,516,375	PPP1R9A/PON1	0.006	0.980	0.007	0.727
		rs655883	11	98,994,584	CNTN5	0.006	0.390	0.001	0.293
		rs1368850	11	130,433,518		0.004	0.387	0.005	0.292
		rs4943116	13	32,995,650	STARD13	0.006	0.205	0.008	0.049
		rs2254191	13	45,344,403		0.007	0.425	0.004	0.116
		rs1620210	13	45,759,488	C13orf18	0.001	0.161	0.004	0.068
		rs2823322	21	15,814,903		0.0004	0.045	0.006	0.029
3c. FBAT: Biologic Age and Walking Speed
Trait 1	Trait 2	SNP	Chr	Physical Position	Gene	Trait 1 GEE p-value	Trait 1 FBAT p-value	Trait 2 GEE p-value	Trait 2 FBAT p-value
Biologic age	Walking speed	rs873348	4	178,246,509		0.135	0.004	0.114	0.006
Biologic age	Walking speed	rs10520361*	4	178,247,037		0.074	0.006	0.054	0.005
Biologic age	Walking speed	rs31564	5	135,258,152	IL9	0.015	0.001	0.008	0.002
Biologic age	Walking speed	rs1862345	5	148,018,498	HTR4	0.172	0.0002	0.399	0.008
Biologic age	Walking speed	rs7844834	8	11,323,556	C8orf12\|C8orf13	0.017	0.004	0.011	0.004
Biologic age	Walking speed	rs952658	12	20,756,568	SLCO1C1	0.024	0.008	0.935	0.006
Biologic age	Walking speed	rs6487366	12	23,994,617	SOX5	0.017	0.003	0.959	0.004
Biologic age	Walking speed	rs7135493	12	28,134,847		0.020	0.006	0.033	0.004
Biologic age	Walking speed	rs10492036	12	124,728,934		0.308	0.005	0.169	0.009
Biologic age	Walking speed	rs1978945	13	105,641,257		0.093	0.009	0.031	0.006
Biologic age	Walking speed	rs2165723*	13	105,641,610		0.046	0.010	0.027	0.003
Biologic age	Walking speed	rs10492651*	13	105,641,634		0.083	0.009	0.023	0.001
Biologic age	Walking speed	rs9301112*	13	105,642,018		0.097	0.004	0.053	0.003
* r² > 0.8 with the preceding SNP (calculated if the distance is <250,000 base pairs)
3d. GEE: Biologic Age and Walking Speed
Trait 1	Trait 2	SNP	Chr	Physical Position	Gene	Trait 1 GEE p-value	Trait 1 FBAT p-value	Trait 2 GEE p-value	Trait 2 FBAT p-value
Biologic Age	Walking speed	rs1474827	6	134,886,011		0.007	0.746	0.000	0.233
Biologic Age	Walking speed	rs10231641	7	119,166,342		0.004	0.077	0.009	0.278
Biologic Age	Walking speed	rs310575	8	51,603,257	SNTG1	0.008	0.209	0.003	0.007
Biologic Age	Walking speed	rs10520603	15	84,170,955		0.009	0.008	0.003	0.050
Biologic Age	Walking speed	rs7166323*	15	84,171,745		0.009	0.012	0.003	0.065
Biologic Age	Walking speed	rs2215921	16	9,604,834		0.007	0.049	0.001	0.316
* r² > 0.8 with the preceding SNP (calculated if the distance is <250,000 base pairs)

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