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Table 2 Aging and Longevity Phenotypes† for FHS 100K Project: Results of Association and Linkage Analyses

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

2a. GEE, Top 5 p-values by Phenotype*
Trait SNP Chromosome Physical location GEE p-value FBAT p-value Gene Region (within 60 kb)
Age at death
  rs1528753 11 90,523,987 8.1 × 10 -8 0.024  
  rs2371208 7 81,982,510 2.6 × 10 -6 0.031  
  rs10496799 2 139,261,401 1.4 × 10 -5 0.735 NXPH2
  rs10489006 4 31,444,987 3.6 × 10 -5 0.078  
  rs3757354 6 16,235,386 6.4 × 10 -5 0.316 MYLIP
Morbidity-free survival at age 65
  rs1412337 1 165,350,299 1.8 × 10 -9 0.505 DPT
  rs32566 5 5,845,507 1.9 × 10 -9 0.323  
  rs10484246 6 9,559,183 8.4 × 10 -8 0.928  
  rs4831837 8 12,756,234 4.7 × 10 -7 0.182  
  rs2639889 16 59,680,648 9.4 × 10 -7 0.903  
Age at natural menopause‡
  rs10496265 2 81,580,466 1.1 × 10 -8 0.001  
  rs10496262* 2 81,662,782 3.3 × 10 -7 0.005  
  rs958672 2 154,896,075 1.9 × 10 -6 0.087 GALNT13
  rs291353 1 232,046,939 5.5 × 10 -6 0.035 GNG4
  rs726336 5 163,911,906 1.1 × 10 -5 0.125  
Walking speed exam 7
  rs7137869 12 118,452,366 6.3 × 10 -7 0.009 CCDC60
  rs7662116 4 154,375,569 1.9 × 10 -5 0.016  
  rs7972859* 12 118,452,765 2.5 × 10 -5 0.005 CCDC60
  rs9318312 13 74,489,506 5.8 × 10 -5 0.266  
  rs1994854 4 78,124,824 9.4 × 10 -5 0.280  
  rs7718104 5 122,183,258 1.2 × 10 -4 0.011 SNX2
Biologic age by osseographic scoring system
  rs1463605 12 30,005,150 7.0 × 10 -8 5.3 × 10-4  
  rs7176093 15 84,170,434 7.4 × 10 -6 0.005 KLHL25
  rs3772255 3 157,585,436 8.2 × 10 -6 0.085 KCNAB1
  rs726846 5 136,099,953 1.1 × 10 -5 0.003  
  rs646983 13 29,413,553 1.2 × 10 -5 0.003  
2b. FBAT, Top 5 p-values by Phenotype*
Trait SNP Chromosome Physical location GEE p-value FBAT p-value Gene Region (within 60 kb)
Age at death
  rs10493513 1 73,091,610 0.640 1.5 × 10 -6  
  rs10493514* 1 73,092,533 0.623 2.8 × 10 -6  
  rs6689491* 1 73,064,050 0.205 2.0 × 10 -5  
  rs10493515 1 73,527,652 0.225 2.3 × 10 -5  
  rs10493518* 1 73,572,652 0.191 3.6 × 10 -5  
  rs10493517* 1 73,570,372 0.215 4.2 × 10 -5  
  rs6657082* 1 73,065,349 0.224 5.5 × 10 -5  
  rs10498263 14 19,285,288 0.310 8.3 × 10 -5 OR4Q3
OR4M1
  rs1915501 4 28,612,632 0.383 1.1 × 10 -4  
  rs1405051* 1 73,060,505 0.176 1.4 × 10 -4  
  rs6459623 6 18,634,791 0.604 1.5 × 10 -4 IBRDC2
Morbidity-free survival at age 65
  rs10509200 10 65,296,567 0.613 7.0 × 10 -5  
  rs965036 6 20,099,022 0.550 8.6 × 10 -5  
  rs720565 6 136,834,657 0.014 9.8 × 10 -5 MAP7
  rs1192372 2 84,923,204 0.094 9.9 × 10 -5  
  rs10505239 8 115,976,403 0.141 1.3 × 10 -4  
Age at natural menopause†
  rs959702 10 2,139,260 0.003 1.4 × 10 -5  
  rs7165378 15 69,478,558 0.006 6.4 × 10 -5  
  rs997161 10 130,876,127 0.074 8.6 × 10 -5  
  rs165284 1 91,235,574 0.006 8.6 × 10 -5 ZNF644
  rs2280585 3 64,882,324 0.884 1.1 × 10 -4  
Walking speed exam 7
  rs4471448 11 86,760,972 0.175 3.8 × 10 -6 TMEM135
  rs336963 5 83,005,460 0.570 2.6 × 10 -5 HAPLN1
  rs7862683 9 18,257,947 0.001 4.9 × 10 -5  
  rs9317757 13 68,458,430 0.252 7.8 × 10 -5  
  rs10501636* 11 86,789,967 0.355 1.1 × 10 -4  
  rs2340392 3 80,440,990 0.002 1.7 × 10 -4  
Biologic age by osseographic scoring system
  rs1380703 2 57,852,938 0.008 1.1 × 10 -5  
  rs324702 4 77,094,969 0.390 3.3 × 10 -5 PPEF2
  rs324735 4 77,062,193 0.096 7.6 × 10 -5  
  rs1106184 2 10,914,125 0.006 8.8 × 10 -5 PDIA6
  rs604578 18 30,923,438 0.004 9.5 × 10 -5 MAPRE2
2c Linkage Peaks with LOD scores ≥ 2.0
Trait SNP closest to linkage peak Chromosome Physical location 1.5 – LOD support interval start 1.5 – LOD support interval end LOD score
Age at natural menopause
  rs1371217 4 182,890,808 178,671,796 186,905,362 2.08
  rs10509024 10 56,567,832 36,084,470 70,573,011 2.39
  rs4793513 17 66,429,892 60,635,492 69,512,021 2.48
Walking speed, exam 7
  rs2769261 1 113,278,949 107,080,550 144,332,709 2.30
  rs921055 2 233,522,842 229,328,008 242,141,304 2.13
  rs2602044 3 109,427,883 102,255,525 111,604,019 3.38
  rs8011773 14 96,927,485 96,342,135 100,389,787 2.69
  rs1362626 16 4,489,227 205,160 10,344,522 2.05
Biologic age by osseographic scoring system
  rs353810 9 86,258,745 81,441,976 92,220,168 3.26
  rs1203981 16 205,160 205,160 7,431,239 2.49
  rs2248383 21 35,151,811 27,412,716 40,940,879 2.22
  1. SNP criteria: Autosomal SNPs with genotypic call rate ≥ 80%, minor allele frequency ≥ 10%, Hardy-Weinberg test p > 0.001, and ≥10 informative families for FBAT
  2. * For each phenotype SNPs are ranked by p-value. A SNP in LD (r2 > 0.8) with a higher ranked SNP, is identified with an asterisk. All SNPs for a phenotype are listed until 5 independent SNPs are identified. Thus, for some phenotypes more than 5 SNPs are listed. For the age at death trait, the FBAT analysis identified two areas on chromosome 1 in LD, with r2 = .5–.6 between the two regions and r2 of nearly 1.0 within the region.
  3. † Multivariable-adjusted trait results are presented
  4. ‡Trait had <500 participants in the sample.
  5. ¶Results limited to traits presented
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