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Table 2 Aging and Longevity Phenotypes† for FHS 100K Project: Results of Association and Linkage Analyses

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

2a. GEE, Top 5 p-values by Phenotype*

Trait

SNP

Chromosome

Physical location

GEE p-value

FBAT p-value

Gene Region (within 60 kb)

Age at death

 

rs1528753

11

90,523,987

8.1 × 10 -8

0.024

 
 

rs2371208

7

81,982,510

2.6 × 10 -6

0.031

 
 

rs10496799

2

139,261,401

1.4 × 10 -5

0.735

NXPH2

 

rs10489006

4

31,444,987

3.6 × 10 -5

0.078

 
 

rs3757354

6

16,235,386

6.4 × 10 -5

0.316

MYLIP

Morbidity-free survival at age 65

 

rs1412337

1

165,350,299

1.8 × 10 -9

0.505

DPT

 

rs32566

5

5,845,507

1.9 × 10 -9

0.323

 
 

rs10484246

6

9,559,183

8.4 × 10 -8

0.928

 
 

rs4831837

8

12,756,234

4.7 × 10 -7

0.182

 
 

rs2639889

16

59,680,648

9.4 × 10 -7

0.903

 

Age at natural menopause‡

 

rs10496265

2

81,580,466

1.1 × 10 -8

0.001

 
 

rs10496262*

2

81,662,782

3.3 × 10 -7

0.005

 
 

rs958672

2

154,896,075

1.9 × 10 -6

0.087

GALNT13

 

rs291353

1

232,046,939

5.5 × 10 -6

0.035

GNG4

 

rs726336

5

163,911,906

1.1 × 10 -5

0.125

 

Walking speed exam 7

 

rs7137869

12

118,452,366

6.3 × 10 -7

0.009

CCDC60

 

rs7662116

4

154,375,569

1.9 × 10 -5

0.016

 
 

rs7972859*

12

118,452,765

2.5 × 10 -5

0.005

CCDC60

 

rs9318312

13

74,489,506

5.8 × 10 -5

0.266

 
 

rs1994854

4

78,124,824

9.4 × 10 -5

0.280

 
 

rs7718104

5

122,183,258

1.2 × 10 -4

0.011

SNX2

Biologic age by osseographic scoring system

 

rs1463605

12

30,005,150

7.0 × 10 -8

5.3 × 10-4

 
 

rs7176093

15

84,170,434

7.4 × 10 -6

0.005

KLHL25

 

rs3772255

3

157,585,436

8.2 × 10 -6

0.085

KCNAB1

 

rs726846

5

136,099,953

1.1 × 10 -5

0.003

 
 

rs646983

13

29,413,553

1.2 × 10 -5

0.003

 

2b. FBAT, Top 5 p-values by Phenotype*

Trait

SNP

Chromosome

Physical location

GEE p-value

FBAT p-value

Gene Region (within 60 kb)

Age at death

 

rs10493513

1

73,091,610

0.640

1.5 × 10 -6

 
 

rs10493514*

1

73,092,533

0.623

2.8 × 10 -6

 
 

rs6689491*

1

73,064,050

0.205

2.0 × 10 -5

 
 

rs10493515

1

73,527,652

0.225

2.3 × 10 -5

 
 

rs10493518*

1

73,572,652

0.191

3.6 × 10 -5

 
 

rs10493517*

1

73,570,372

0.215

4.2 × 10 -5

 
 

rs6657082*

1

73,065,349

0.224

5.5 × 10 -5

 
 

rs10498263

14

19,285,288

0.310

8.3 × 10 -5

OR4Q3

OR4M1

 

rs1915501

4

28,612,632

0.383

1.1 × 10 -4

 
 

rs1405051*

1

73,060,505

0.176

1.4 × 10 -4

 
 

rs6459623

6

18,634,791

0.604

1.5 × 10 -4

IBRDC2

Morbidity-free survival at age 65

 

rs10509200

10

65,296,567

0.613

7.0 × 10 -5

 
 

rs965036

6

20,099,022

0.550

8.6 × 10 -5

 
 

rs720565

6

136,834,657

0.014

9.8 × 10 -5

MAP7

 

rs1192372

2

84,923,204

0.094

9.9 × 10 -5

 
 

rs10505239

8

115,976,403

0.141

1.3 × 10 -4

 

Age at natural menopause†

 

rs959702

10

2,139,260

0.003

1.4 × 10 -5

 
 

rs7165378

15

69,478,558

0.006

6.4 × 10 -5

 
 

rs997161

10

130,876,127

0.074

8.6 × 10 -5

 
 

rs165284

1

91,235,574

0.006

8.6 × 10 -5

ZNF644

 

rs2280585

3

64,882,324

0.884

1.1 × 10 -4

 

Walking speed exam 7

 

rs4471448

11

86,760,972

0.175

3.8 × 10 -6

TMEM135

 

rs336963

5

83,005,460

0.570

2.6 × 10 -5

HAPLN1

 

rs7862683

9

18,257,947

0.001

4.9 × 10 -5

 
 

rs9317757

13

68,458,430

0.252

7.8 × 10 -5

 
 

rs10501636*

11

86,789,967

0.355

1.1 × 10 -4

 
 

rs2340392

3

80,440,990

0.002

1.7 × 10 -4

 

Biologic age by osseographic scoring system

 

rs1380703

2

57,852,938

0.008

1.1 × 10 -5

 
 

rs324702

4

77,094,969

0.390

3.3 × 10 -5

PPEF2

 

rs324735

4

77,062,193

0.096

7.6 × 10 -5

 
 

rs1106184

2

10,914,125

0.006

8.8 × 10 -5

PDIA6

 

rs604578

18

30,923,438

0.004

9.5 × 10 -5

MAPRE2

2c Linkage ¶ Peaks with LOD scores ≥ 2.0

Trait

SNP closest to linkage peak

Chromosome

Physical location

1.5 – LOD support interval start

1.5 – LOD support interval end

LOD score

Age at natural menopause

 

rs1371217

4

182,890,808

178,671,796

186,905,362

2.08

 

rs10509024

10

56,567,832

36,084,470

70,573,011

2.39

 

rs4793513

17

66,429,892

60,635,492

69,512,021

2.48

Walking speed, exam 7

 

rs2769261

1

113,278,949

107,080,550

144,332,709

2.30

 

rs921055

2

233,522,842

229,328,008

242,141,304

2.13

 

rs2602044

3

109,427,883

102,255,525

111,604,019

3.38

 

rs8011773

14

96,927,485

96,342,135

100,389,787

2.69

 

rs1362626

16

4,489,227

205,160

10,344,522

2.05

Biologic age by osseographic scoring system

 

rs353810

9

86,258,745

81,441,976

92,220,168

3.26

 

rs1203981

16

205,160

205,160

7,431,239

2.49

 

rs2248383

21

35,151,811

27,412,716

40,940,879

2.22

  1. SNP criteria: Autosomal SNPs with genotypic call rate ≥ 80%, minor allele frequency ≥ 10%, Hardy-Weinberg test p > 0.001, and ≥10 informative families for FBAT
  2. * For each phenotype SNPs are ranked by p-value. A SNP in LD (r2 > 0.8) with a higher ranked SNP, is identified with an asterisk. All SNPs for a phenotype are listed until 5 independent SNPs are identified. Thus, for some phenotypes more than 5 SNPs are listed. For the age at death trait, the FBAT analysis identified two areas on chromosome 1 in LD, with r2 = .5–.6 between the two regions and r2 of nearly 1.0 within the region.
  3. † Multivariable-adjusted trait results are presented
  4. ‡Trait had <500 participants in the sample.
  5. ¶Results limited to traits presented
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BMC Medical Genetics

ISSN: 1471-2350

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