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Table 1 Aging and Longevity Phenotypes for Framingham Heart Study 100K Project

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

   

Exam cycle(s)

 

Phenotype Subgroup

• Trait (variable name on the website*)

Number of Traits

N (MV**)

Offspring / Original Cohort

 

Adjustment

Survival Traits: Cox regression

Survival

• Age at death (1. deathageX, 2. deathageMV)

2

1345 (1166)

Cohort & Offspring pooled

 

Cox regression

Sex-specific

1. birth cohort

2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1

Categorical traits: Logistic regression

• Survival past the ALE (1. deathpastALEX, 2. deathpastALEMV)

2

1345 (1166)

Cohort & Offspring pooled

 

Logistic regression

Sex-specific

1. birth cohort

2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1

Morbidity-free survival (free of CVD, cancer and dementia)

• At age 65 years (1. morbidityfree65X, 2. morbidityfree65MVX)

2

558 (558)

Cohort & Offspring pooled, exams closest to age 65 years

 

Logistic regression

Sex-specific

1. birth cohort

2. multivariable adjusted for birth cohort, education, smoking, obesity, CVD risk factors measured at exam closest to age 65 years (within a 5 year horizon)

Quantitative Traits: Linear regression

Reproductive Aging

• Age at natural menopause (1. menoageX, 2. menoageMVX)

2

438 (378)

Cohort & Offspring pooled, women only

 

Linear regression

1. crude

2. multivariable adjusted for smoking, BMI, parity, generation (measured at exams prior to menopause)

Cognitive function

• MMSE at age 65 years (1. MMSE65X, 2. MMSE65MVX)

• MMSE at the specified Offspring exam (1. MMSE5X, 2. MMSE5MVX, 1. MMSE7X, 2. MMSE7MV, 1. MMSE5to7X, 2. MMSE5to7MVX)

2

593 (462)

Cohort & Offspring pooled, exams at age 65

 

Linear regression

Sex-specific

1. birth cohort

2. multivariable adjusted for birth cohort, education, FSRP measured at exam closest to age 65 years (5 year horizon)

 

6

1038 (913)

Exam 5

Exam 7

Exam 5 & 7

average score

 

Linear regression

Sex-specific

1. birth cohort

2. multivariable adjusted for birth cohort, education, FSRP; covariates measured at the specified exam

Physical Performance

• Hand grip (2. handgrip7x, 2. handgrips727x)

• Walking speed (2. walkingspeed7x, 2. walkingspeed727x)

6

764

Exam 7

Exam 7 and Exam 27

 

Linear regression

Sex-specific‡

1. age

2. multivariable adjusted for age, height, weight at the specified exam

Biologic Age by Osseographic Scoring System (1. deltaOSSr, delta OSSrf, deltaOSSrm)

3

714

Offspring and Cohort pooled

exam 6/7 and exam 22

 

Linear regression

Sex- and cohort-specific ranked residuals§

1. multivariable adjusted for age, height, BMI, menopause, estrogen use

  1. Residuals from these models were used as traits to test for association with SNP genotypes.
  2. * The number preceding the variable name refers to the covariate adjustment in the last column of the table. The website with all results is found at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007; ** MV = N for multivariable trait
  3. ‡ cohort- and sex-specific residuals for traits that included both cohort and offspring; §cohort-specific for traits limited to one sex
  4. ALE = average life expectancy, BMI = body mass index, Co-morbidity = cardiovascular disease and cancer, CVD = cardiovascular disease, FSRP = Framingham stroke risk profile, MMSE = mini-mental state exam, Risk factors = hypertension, diabetes, elevated cholesterol
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BMC Medical Genetics

ISSN: 1471-2350

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