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Table 1 Aging and Longevity Phenotypes for Framingham Heart Study 100K Project

From: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

    Exam cycle(s)  
Phenotype Subgroup
• Trait (variable name on the website*)
Number of Traits N (MV**) Offspring / Original Cohort   Adjustment
Survival Traits: Cox regression
Survival
• Age at death (1. deathageX, 2. deathageMV)
2 1345 (1166) Cohort & Offspring pooled   Cox regression
Sex-specific
1. birth cohort
2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1
Categorical traits: Logistic regression
• Survival past the ALE (1. deathpastALEX, 2. deathpastALEMV) 2 1345 (1166) Cohort & Offspring pooled   Logistic regression
Sex-specific
1. birth cohort
2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1
Morbidity-free survival (free of CVD, cancer and dementia)
• At age 65 years (1. morbidityfree65X, 2. morbidityfree65MVX)
2 558 (558) Cohort & Offspring pooled, exams closest to age 65 years   Logistic regression
Sex-specific
1. birth cohort
2. multivariable adjusted for birth cohort, education, smoking, obesity, CVD risk factors measured at exam closest to age 65 years (within a 5 year horizon)
Quantitative Traits: Linear regression
Reproductive Aging
• Age at natural menopause (1. menoageX, 2. menoageMVX)
2 438 (378) Cohort & Offspring pooled, women only   Linear regression
1. crude
2. multivariable adjusted for smoking, BMI, parity, generation (measured at exams prior to menopause)
Cognitive function
• MMSE at age 65 years (1. MMSE65X, 2. MMSE65MVX)
• MMSE at the specified Offspring exam (1. MMSE5X, 2. MMSE5MVX, 1. MMSE7X, 2. MMSE7MV, 1. MMSE5to7X, 2. MMSE5to7MVX)
2 593 (462) Cohort & Offspring pooled, exams at age 65   Linear regression
Sex-specific
1. birth cohort
2. multivariable adjusted for birth cohort, education, FSRP measured at exam closest to age 65 years (5 year horizon)
  6 1038 (913) Exam 5
Exam 7
Exam 5 & 7
average score
  Linear regression
Sex-specific
1. birth cohort
2. multivariable adjusted for birth cohort, education, FSRP; covariates measured at the specified exam
Physical Performance
• Hand grip (2. handgrip7x, 2. handgrips727x)
• Walking speed (2. walkingspeed7x, 2. walkingspeed727x)
6 764 Exam 7
Exam 7 and Exam 27
  Linear regression
Sex-specific‡
1. age
2. multivariable adjusted for age, height, weight at the specified exam
Biologic Age by Osseographic Scoring System (1. deltaOSSr, delta OSSrf, deltaOSSrm) 3 714 Offspring and Cohort pooled
exam 6/7 and exam 22
  Linear regression
Sex- and cohort-specific ranked residuals§
1. multivariable adjusted for age, height, BMI, menopause, estrogen use
  1. Residuals from these models were used as traits to test for association with SNP genotypes.
  2. * The number preceding the variable name refers to the covariate adjustment in the last column of the table. The website with all results is found at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007; ** MV = N for multivariable trait
  3. ‡ cohort- and sex-specific residuals for traits that included both cohort and offspring; §cohort-specific for traits limited to one sex
  4. ALE = average life expectancy, BMI = body mass index, Co-morbidity = cardiovascular disease and cancer, CVD = cardiovascular disease, FSRP = Framingham stroke risk profile, MMSE = mini-mental state exam, Risk factors = hypertension, diabetes, elevated cholesterol
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