Table 5 Top 10 ranked SNPs in combining GEE association tests of ADP-induced, Collagen-induced and Epi-induced platelet aggregation levels
| Â | Â | Â | Â | Â | Â | Â | Â | Â | GEE P-value of individual phenotypes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | MAF | CHR | Physical Position (bp)* | Mean GEE p-value | Range of Beta Coefficient†(min, max) | Number of Phenotypes with GEE P-value < 0.01 | Gene within 60 Kb | ADP | Collagen | Epi | |
rs10500631 | 0.13 | 11 | 4,882,639 | 6.6 × 10-3 | 0.19 | 0.24 | 3 | OR51S1; OR51T1; OR51A7; OR51G2; OR51G1; OR51A4; OR51A2 | 9.7 × 10-3 | 7.8 × 10-3 | 3.8 × 10-3 |
rs930323 | 0.18 | 1 | 221,172,525 | 1.9 × 10-3 | -0.26 | -0.16 | 2 | CNIH3 | 3.8 × 10-2 | 1.6 × 10-3 | 1.2 × 10-4 |
rs7033457 | 0.25 | 9 | 7,383,934 | 2.6 × 10-3 | 0.15 | 0.24 | 2 |  | 2.5 × 10-3 | 3.7 × 10-2 | 2.0 × 10-4 |
rs2974490 | 0.11 | 5 | 113,433,775 | 2.7 × 10-3 | 0.07 | 0.28 | 2 |  | 4.2 × 10-1 | 8.7 × 10-5 | 5.2 × 10-4 |
rs10517543 | 0.13 | 4 | 40,332,115 | 3.2 × 10-3 | 0.13 | 0.27 | 2 | AF262323; FLJ20273 | 5.8 × 10-3 | 1.0 × 10-1 | 5.2 × 10-5 |
rs2916601 | 0.13 | 5 | 89,556,637 | 3.5 × 10-3 | 0.11 | 0.29 | 2 |  | 9.7 × 10-2 | 3.2 × 10-4 | 1.4 × 10-3 |
rs4350297 | 0.18 | 10 | 106,463,038 | 3.9 × 10-3 | -0.24 | -0.10 | 2 | SORCS3 | 3.5 × 10-4 | 1.0 × 10-1 | 1.7 × 10-3 |
rs7956194 | 0.42 | 12 | 108,340,545 | 4.3 × 10-3 | 0.09 | 0.20 | 2 | FLJ37587; KCTD10; BC040062; AK056912; BC051266; UBE3B | 3.6 × 10-3 | 1.1 × 10-1 | 2.0 × 10-4 |