Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study

Table 4 Maximum LOD scores (≥2) on each chromosomes for hemostatic factors and hematological phenotypes

Phenotype*	SNP	CHR	Physical Position (bp)^†	LOD	1.5 LOD Support Interval
Fibrinogen	rs1273819	2	227,307,918	2.4	221,455,139	234,213,322
FVII	rs1542535	3	138,548,560	2.8	128,478,856	147,720,726
FVII	rs2400107	10	15,113,999	3.3	13,834,912	21,013,729
PAI1	143xd8	8	2,117,752	2.3	181,076	5,519,520
vWF	rs10514670	3	18,544,296	2.1	9,261,438	25,964,778
platelet aggregation (ADP-induced)	rs4148751	7	86,787,804	2.0	81,841,699	94,233,832
platelet aggregation (collagen-induced)	rs17310225	X	41,973,417	2.1	30,937,095	81,367,217
Hgb	rs2412522	4	54,779,471	3.4	41,552,790	57,899,713
Hgb	rs10514838	9	120,826,350	2.5	113,537,965	133,903,932
MCVavg12	rs38993	7	153,013,905	2.2	149,613,755	154,729,817
MCVavg12	rs9299952	11	19,075,037	3.3	12,241,666	21,560,867
MCVavg12	rs10522006	X	32,347,187	2.3	27,553,388	40,183,712
RBCC	rs956275	4	57,108,334	2.5	44,437,719	74,935,678
RBCC	rs2023048	6	162,441,307	2.9	156,253,205	165,513,097
RBCC	rs10500769	11	12,975,794	3.2	9,335,581	15,231,734
RBCC	rs10500770	11	13,053,050	3.2	9,335,581	15,231,734
RBCC	rs2178692	12	6,706,312	2.8	4,817,859	9,212,944
RBCC	rs10498633	14	91,996,705	2.6	74,270,406	93,717,052
RBCC	GATA27A03	15	100,152,332	2.3	98,566,644	100,152,332
RBCC	rs2271090	17	76,861,200	2.3	73,915,579	78,166,561
RBCC	rs486633	18	555,760	3.3	156,277	4,009,209
RBCC	rs20037	22	27,802,395	2.2	25,095,430	42,711,182

* For Hgb, MCH and RBCC reported here, multivariable adjusted residuals from average of measurements over exam cycles 1 and 2 were used; for all platelet aggregation phenotypes, fibrinogen, FVII, PAI1, vWF reported here, multivariable adjusted residuals from measurements at examination cycle 5 were used.
^†Physical position is in base pair (bp) and based on the May 2004 human reference sequence (NCBI Build 35).

ISSN: 1471-2350