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Table 3 The 25 SNPs with lowest GEE association tests p-values with hematological phenotypes

From: Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study

Phenotype*

SNP

MAF

CHR

Physical Position (bp)†

GEE Pval (Rank)††

FBAT Pval†††

Genes within 60 Kb

Hgb

rs4133289

0.19

1

156,267,010

1.6 × 10 -7 (2)

6.0 × 10-4

OR10J1; OR10J5

Hgb

rs1510107

0.41

2

53,071,788

1.0 × 10 -5 (17)

2.2 × 10-3

 

Hgb

rs1160297

0.43

2

53,148,971

1.0 × 10 -6 (4)

8.3 × 10-4

 

Hgb

rs2357013

0.45

2

53,177,780

6.1 × 10 -6 (14)

1.3 × 10-3

 

Hgb

rs7844723

0.45

8

122,977,684

2.1 × 10 -6 (5)

2.6 × 10-3

 

MCH

rs1829883

0.41

5

98,809,002

5.8 × 10 -6 (11)

1.4 × 10-2

 

MCH

rs1200821

0.47

10

37,599,586

5.9 × 10 -6 (13)

1.0 × 10-1

ANKRD30A

MCH

rs1397048

0.40

11

56,222,675

6.9 × 10 -8 (1)

1.0 × 10-2

OR5AP2; OR5AR1; OR9G1; OR9G4

platelet aggregation (ADP-induced)

rs10493895

0.19

1

97,983,247

1.6 × 10 -5 (23)

4.5 × 10-2

BC064027; DPYD

platelet aggregation (ADP-induced)

rs10484128

0.15

14

97,712,325

5.8 × 10 -6 (12)

1.3 × 10-3

 

platelet aggregation (collagen-induced)

rs848523

0.42

2

36,659,307

2.1 × 10 -5 (24)

4.3 × 10-1

CRIM1

platelet aggregation (collagen-induced)

rs565229

0.10

11

121,694,675

3.7 × 10 -6 (6)

2.6 × 10-2

 

platelet aggregation (collagen-induced)

rs10506458

0.13

12

61,731,359

4.5 × 10 -6 (9)

1.1 × 10-4

 

platelet aggregation (Epi-induced)

rs6811964

0.11

4

158,143,059

1.3 × 10 -5 (20)

5.5 × 10-2

PDGFC

platelet aggregation (Epi-induced)

rs1958208

0.32

14

81,194,793

1.1 × 10 -5 (18)

7.0 × 10-1

 

platelet aggregation (Epi-induced)

rs10502583

0.17

18

28,011,131

1.1 × 10 -5 (19)

1.1 × 10-2

RNF138; MEP1B

RBCC

rs9253

0.18

1

37,627,906

4.2 × 10 -6 (7)

1.1 × 10-5

FLJ11730; BC016328

RBCC

rs10489087

0.13

4

13,470,685

4.5 × 10 -6 (8)

9.6 × 10-4

 

RBCC

rs636864

0.21

6

149,567,299

6.3 × 10 -6 (15)

1.3 × 10-4

 

RBCC

rs727979

0.14

6

149,635,613

7.5 × 10 -6 (16)

2.6 × 10-5

MAP3K7IP2

RBCC

rs6108011

0.28

20

7,500,504

5.8 × 10 -6 (10)

7.0 × 10-2

 

Viscosity

rs10490258

0.11

2

40,717,605

1.5 × 10 -5 (21)

2.9 × 10-2

 

Viscosity

rs1359339

0.18

6

18,606,507

2.2 × 10 -5 (25)

2.3 × 10-2

IBRDC2

Viscosity

rs10485968

0.20

7

81,108,037

1.6 × 10 -5 (22)

3.0 × 10-3

 

Viscosity

rs7159841

0.21

14

46,933,585

2.1 × 10 -7 (3)

2.0 × 10-1

MAMDC1

  1. * For Hgb, MCH and RBCC reported here, multivariable adjusted residuals from average of measurements over exam cycles 1 and 2 were used; for all platelet aggregation phenotypes, and viscosity reported here, multivariable adjusted residuals from measurements at examination cycle 5 were used.
  2. †Physical position is in base pair (bp) and based on the May 2004 human reference sequence (NCBI Build 35).
  3. ††P-value from GEE genotype association test and rank of the GEE p-values in ascending order.
  4. †††P-value from family-based association test using the FBAT program.
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BMC Medical Genetics

ISSN: 1471-2350

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