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Table 2 The 25 SNPs with lowest GEE association test p-values with hemostatic factors measured at exam 5

From: Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study

Phenotype*

SNP

MAF

CHR

Physical Position (bp)†

GEE p-val (Rank)††

FBAT p-val†††

Genes within 60 kb

Fibrinogen

rs6683832

0.41

1

62,988,925

5.6 × 10 -5 (4)

3.4 × 10-2

APG4C

Fibrinogen

rs4861952

0.11

4

182,696,179

3.5 × 10 -5 (24)

8.2 × 10-3

 

Fibrinogen

rs10506540

0.12

12

65,699,364

2.2 × 10 -5 (16)

3.3 × 10-2

 

Fibrinogen

rs974673

0.15

14

33,550,265

3.1 × 10 -5 (19)

1.3 × 10-3

 

FVII

rs966321

0.47

1

4,225,577

7.6 × 10 -6 (6)

4.5 × 10-2

 

FVII

rs1245072

0.17

1

69,827,777

1.8 × 10 -5 (13)

7.5 × 10-3

LRRC7

FVII

rs2362932

0.24

1

242,240,325

2.4 × 10 -5 (17)

1.5 × 10-2

SMYD3

FVII

rs10496112

0.30

2

64,535,384

3.3 × 10 -5 (23)

7.4 × 10-3

HSPC159

FVII

rs1001254

0.13

3

7,909,333

2.0 × 10 -5 (14)

2.0 × 10-2

 

FVII

rs4591494

0.19

3

7,957,827

9.2 × 10 -6 (7)

1.2 × 10-4

 

FVII

rs10488360

0.30

7

4,184,450

7.2 × 10 -6 (5)

9.3 × 10-3

 

FVII

rs727435

0.13

9

80,809,022

9.6 × 10 -6 (8)

2.8 × 10-2

 

FVII

rs7938734

0.31

11

49,834,857

3.2 × 10 -5 (21)

7.0 × 10-2

 

FVII

rs561241

0.12

13

112,808,035

4.5 × 10 -16 (1)

3.4 × 10-4

MCF2L; AB116074; AK092739; AK123267; AB002360; F7; CR603372; F10; PROZ

PAI1

rs10490733

0.14

2

137,872,229

3.2 × 10 -5 (22)

2.4 × 10-2

 

PAI1

rs4460176

0.29

5

109,524,859

3.1 × 10 -6 (3)

7.6 × 10-2

 

tPA

rs10493485

0.29

1

71,783,150

1.6 × 10 -6 (2)

1.1 × 10-3

BC036771; NEGR1

tPA

rs10494076

0.32

1

108,050,369

3.1 × 10 -5 (20)

2.3 × 10-2

VAV3

tPA

rs2029637

0.25

3

113,404,510

1.3 × 10 -5 (10)

6.1 × 10-2

SLC9A10

tPA

rs953377

0.28

6

23,998,670

1.5 × 10 -5 (11)

3.4 × 10-2

 

vWF

rs9295740

0.14

6

27,797,481

2.8 × 10 -5 (18)

5.7 × 10-3

 

vWF

rs202906

0.12

6

28,119,631

2.1 × 10 -5 (15)

1.1 × 10-1

ZNF165

vWF

rs708356

0.35

12

128,998,794

1.5 × 10 -5 (12)

2.4 × 10-2

AK127723

vWF

rs1954971

0.38

18

26,633,241

1.0 × 10 -5 (9)

1.6 × 10-2

 

vWF

rs7319671

0.30

13

36,923,224

3.6 × 10 -5 (25)

1.1 × 10-2

 
  1. * All the phenotypes reported here were multivariable adjusted residuals from the measurements obtained at exam cycle 5.
  2. †Physical position is in base pair (bp) and based on the May 2004 human reference sequence (NCBI Build 35).
  3. ††P-value from GEE genotype association test and rank of the GEE p-values in ascending order.
  4. †††P-value from family-based association test using the FBAT program.