4a. Results of GEE analysis between SNPs in the CST3 and APOE candidate genes and the kidney function traits with p-value < 0.05. Corresponding phenotype names on the web are CYSMV7 (CysC) and CKDMV7 (CKD). | |||||||
---|---|---|---|---|---|---|---|
Candidate gene | PHENOTYPE | SNP | CHROMOSOME | Location | Minor allele frequency(%) | P_value (GEE) | Partial R2 |
CST3 | CysC | rs1158167 | 20 | 23,526,189 | 21 | 8.0 *10-9 | 2.5 |
CST3 | CysC | rs2145231 | 20 | 23,573,547 | 15 | 1.1*10-5 | 1.2 |
CST3 | CysC | rs726217 | 20 | 23,532,116 | 38 | 3.1*10-4 | 0.8 |
CST3 | CysC | rs911122 | 20 | 23,573,746 | 37 | 0.007 | 1.1 |
APOE | CKD | rs3760626 | 19 | 50,148,945 | 45 | 0.04 | - |
4b. Results of FBAT analysis between SNPs in the CST3 candidate gene and kidney function traits with p-value < 0.05. Corresponding phenotype names on the web are CYSMV7 (CysC) and UAEGE30HTNMV6 (UAE ≥ 30 mg/g) | |||||||
Candidate gene | PHENOTYPE | SNP | CHROMOSOME | Location | P-value | Â | Â |
CST3 | CysC | rs1158167 | 20 | 23,526,189 | 0.006 | Â | Â |
CST3 | CysC | rs2145231 | 20 | 23,573,547 | 0.011 | Â | Â |
CST3 | UAE ≥ 30* | rs911122 | 20 | 23,573,746 | 0.032 |  |  |