Table 3 SNPs showing the top 8 significant association with multiple measurements of GFR, UACR, or TSH phenotypes.* Corresponding phenotype names on the web are GFRMV7 (GFR), UAELNMV6 (UAE), and TSHMEAN34MV (TSH).
Trait | chromosome | SNP (rsID) | Physical Location | Genes (in or near) | Mean p-value (GEE) | Mean p-value (FBAT) |
|---|---|---|---|---|---|---|
GFR | 21 | rs2839235 | 46625020 | PCNT2 | 6.3*10-4 | 0.281 |
GFR | 17 | rs10512437 | 27046466 | Â | 0.002 | 0.197 |
GFR | 13 | rs2480555 | 70785310 | DACH1 | 0.003 | 0.006 |
GFR | 7 | rs10486135 | 11301740 | Â | 0.004 | 0.142 |
GFR | 7 | rs727087 | 8244570 | ICA1 | 0.004 | 0.223 |
GFR | 13 | rs1005066 | 70790573 | DACH1 | 0.004 | 0.022 |
GFR | 18 | rs2885618 | 41244839 | SETBP1 | 0.004 | 0.024 |
GFR | 2 | rs10496887 | 142198571 | LRP1B | 0.005 | 0.091 |
UAE | 11 | rs1712790 | 114126679 | FAM55D | 9.1*10-07 | 0.009 |
UAE | 6 | rs10485409 | 91562132 | EPHA7 | 1.0*10-05 | 0.067 |
UAE | 21 | rs9305354 | 28397067 | Â | 1.9*10-05 | 0.018 |
UAE | 11 | rs10502192 | 114127562 | FAM55D | 3.6*10-05 | 0.041 |
UAE | 1 | rs2077678 | 75246848 | Â | 4.4*10-05 | 0.022 |
UAE | 4 | rs723464 | 133940196 | Â | 4.9*10-05 | 0.000 |
UAE | 21 | rs9305355 | 28397088 | Â | 5.0*10-05 | 0.011 |
UAE | 6 | rs10484587 | 143183270 | AIG1 | 5.2*10-05 | 0.032 |
TSH | 7 | rs6977660 | 19578720 | Â | 1.6*10-05 | 0.022 |
TSH | 4 | rs10493147 | 129095104 | HSPA4L | 2.1*10-05 | 0.019 |
TSH | 7 | rs10499559 | 21882699 | DNAH11 | 2.8*10-05 | 0.111 |
TSH | 6 | rs9322817 | 105338926 | Â | 7.4*10-05 | 0.576 |
TSH | 2 | rs9308765 | 118759439 | INSIG2 | 7.7*10-05 | 0.404 |
TSH | 6 | rs6942231 | 105298507 | Â | 1.6*10-04 | 0.541 |
TSH | 7 | rs10486365 | 19574604 | Â | 1.9*10-04 | 0.221 |
TSH | 7 | rs10486653 | 34484903 | BMPER | 2.7*10-04 | 0.252 |