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Table 1 Traits names, Framingham Heart Study examination cycle, and multivariable adjustments

From: A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study

Trait

Sample size

Exam cycle/s

 
  

Offspring

Original Cohort

Adjustment†

Serum Creatinine

840–1010

2, 5, 6, 7

0

Age and sex; multivariable*

Change in serum creatinine

854

2, 7

0

Age and sex; multivariable*

Glomerular Filtration Rate (GFR)

840–1010

2, 5, 6, 7

0

Age and sex; multivariable*

Chronic Kidney Disease

1010

7

0

Age and sex; multivariable*

Cystatin C

981

7

0

Age and sex; multivariable*

Uric acid

912–1031

1, 2

0

Age and sex; multivariable*

Urinary Albumin Excretion

822

6

0

Age and sex; multivariable*

Urinary Albumin Excretion ≥ 30 mg/g; Hypertension-enriched sample

532

6

0

Age and sex; multivariable*

Serum Calcium

906

2

0

Age and sex; age, sex, serum creatinine

Serum Phosphorus

911

2

0

Age and sex; age, sex, and serum creatinine

Thyroid stimulation hormone (TSH)

883

3

0

Age and sex; age, sex, body mass index, smoking, menopausal status, thyroid hormone use

Mean of TSH exam 3 & 4

810

3, 4

0

Age and sex; age, sex, body mass index, smoking, menopausal status, thyroid hormone use

Luteinizing hormone (LH) **

508

3

0

Age and multivariable***

Follicle stimulating hormone (FSH)**

509

3

0

Age and multivariable***

Dehydroepiandrosterone sulfate (DHEAS)

850

3

0

Age and sex; multivariable***

  1. *Multivariable adjustment include age, sex, systolic blood pressure, hypertension treatment, HDL-cholesterol, smoking, diabetes, body mass index
  2. **Men and post-menopausal women only with natural menopause not using hormone replacement treatment or oral contraceptive pills
  3. *** Age, diabetes mellitus, impaired fasting glucose, smoking, systolic blood pressure, diastolic blood pressure, body-mass index, hypertension treatment, prevalent cardiovascular disease, total cholesterol/HDL ratio and alcohol intake