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Table 5 Comparison of biochemical data of the low HDL-C and control subjects between the most prevalent genotypes of the hexanucleotide repeat polymorphism in the SMPD1 gene.

From: Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

 

Control subjects (n = 230)

t test p

Low HDL-C subjects (n = 118)

t test p*

 

6/6

6/7

7/7

 

6/6

6/7

7/7

 

n

45

101

45

 

29

43

30

 

Age (y)

50 ± 8

50 ± 9

49 ± 9

0.79

48 ± 10

51 ± 10

49 ± 10

0.51

Gender (M/F)

30/15

68/33

29/16

0.94

22/7

29/14

20/10

0.69

BMI (kg/m2)

26.1 ± 5.1

26.4 ± 4.0

26.0 ± 4.1

0.86

27.9 ± 4.2

27.8 ± 5.1

29.2 ± 5.6

0.45

DM (%)

15.0

55.0

30.0

0.57

19.0

42.9

38.1

0.47

HTN (%)

23.1

61.5

15.4

0.35

22.2

35.6

42.2

0.04

CAD (%)

26.1

51.1

22.8

0.77

23.9

45.1

31.0

0.16

FH of CAD (%)

28.3

53.3

18.3

0.05

23.6

43.1

33.3

0.15

TG (mmol/L)

1.60 ± 0.68

1.56 ± 0.85

1.68 ± 0.88

0.71

2.73 ± 1.38

4.94 ± 3.65

3.57 ± 2.58

0.005

T Chol (mmol/L)

6.09 ± 1.45

5.61 ± 1.52

5.82 ± 1.32

0.19

5.56 ± 2.21

6.12 ± 1.77

6.03 ± 2.06

0.48

HDL-C (mmol/L)

1.36 ± 0.34

1.33 ± 0.31

1.31 ± 0.28

0.80

0.66 ± 0.11

0.67 ± 0.13

0.69 ± 0.10

0.55

LDL-C (mmol/L)

3.96 ± 1.37

3.60 ± 1.34

3.79 ± 1.39

0.32

3.60 ± 2.08

3.38 ± 1.34

3.68 ± 1.62

0.74

  1. BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease; FH, familial history; TG, plasma triglycerides; T Chol, plasma cholesterol; HDL-C, plasma high-density lipoprotein cholesterol; LDL-C, plasma low density lipoprotein cholesterol.
  2. significantly different from genotype 6/6.
  3. * significant p value bolded.