Skip to main content

Table 5 Comparison of biochemical data of the low HDL-C and control subjects between the most prevalent genotypes of the hexanucleotide repeat polymorphism in the SMPD1 gene.

From: Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

  Control subjects (n = 230) t test p Low HDL-C subjects (n = 118) t test p*
  6/6 6/7 7/7   6/6 6/7 7/7  
n 45 101 45   29 43 30  
Age (y) 50 ± 8 50 ± 9 49 ± 9 0.79 48 ± 10 51 ± 10 49 ± 10 0.51
Gender (M/F) 30/15 68/33 29/16 0.94 22/7 29/14 20/10 0.69
BMI (kg/m2) 26.1 ± 5.1 26.4 ± 4.0 26.0 ± 4.1 0.86 27.9 ± 4.2 27.8 ± 5.1 29.2 ± 5.6 0.45
DM (%) 15.0 55.0 30.0 0.57 19.0 42.9 38.1 0.47
HTN (%) 23.1 61.5 15.4 0.35 22.2 35.6 42.2 0.04
CAD (%) 26.1 51.1 22.8 0.77 23.9 45.1 31.0 0.16
FH of CAD (%) 28.3 53.3 18.3 0.05 23.6 43.1 33.3 0.15
TG (mmol/L) 1.60 ± 0.68 1.56 ± 0.85 1.68 ± 0.88 0.71 2.73 ± 1.38 4.94 ± 3.65 3.57 ± 2.58 0.005
T Chol (mmol/L) 6.09 ± 1.45 5.61 ± 1.52 5.82 ± 1.32 0.19 5.56 ± 2.21 6.12 ± 1.77 6.03 ± 2.06 0.48
HDL-C (mmol/L) 1.36 ± 0.34 1.33 ± 0.31 1.31 ± 0.28 0.80 0.66 ± 0.11 0.67 ± 0.13 0.69 ± 0.10 0.55
LDL-C (mmol/L) 3.96 ± 1.37 3.60 ± 1.34 3.79 ± 1.39 0.32 3.60 ± 2.08 3.38 ± 1.34 3.68 ± 1.62 0.74
  1. BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease; FH, familial history; TG, plasma triglycerides; T Chol, plasma cholesterol; HDL-C, plasma high-density lipoprotein cholesterol; LDL-C, plasma low density lipoprotein cholesterol.
  2. significantly different from genotype 6/6.
  3. * significant p value bolded.