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Table 3 Comparison of biochemical data of the low HDL-C and control subjects between different groups of G1522A genotypes.

From: Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

  Control subjects t test p* Low HDL-C subjects t test p*
  GG AG + AA   GG AG + AA  
n 129 101   75 42  
Age (y) 50 ± 10 50 ± 8 0.5 49 ± 9 51 ± 11 0.4
Gender (M/F) 81/48 69/32 0.3 52/23 32/10 0.4
BMI (kg/m2) 26.4 ± 4.6 26.3 ± 4.4 0.9 28.3 ± 5.2 27.7 ± 4.5 0.5
DM (%) 10.5 10.9 0.9 20.3 19.0 0.9
HTN (%) 19.3 22.8 0.5 51.3 33.3 0.06
CAD (%) 45.9 56.0 0.1 75.4 65.8 0.3
FH of CAD (%) 51.7 75.8 0.0003 75.0 67.5 0.4
TG (mmol/L) 1.60 ± 0.89 1.70 ± 0.89 0.4 4.34 ± 3.89 3.19 ± 1.90 0.07
T Chol (mmol/L) 5.55 ± 1.19 5.96 ± 1.62 0.03 6.33 ± 2.39 5.25 ± 1.56 0.009
HDL-C (mmol/L) 1.34 ± 0.31 1.33 ± 0.33 0.8 0.67 ± 0.13 0.67 ± 0.13 0.9
LDL-C (mmol/L) 3.51 ± 1.10 3.93 ± 1.54 0.02 3.71 ± 1.74 3.17 ± 1.34 0.09
  1. BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease; FH, familial history; TG, plasma triglycerides; T Chol, total plasma cholesterol; HDL-C, plasma high-density lipoprotein cholesterol; LDL-C, plasma low-density cholesterol.
  2. * significant p-value bolded.