From: The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans
 | Control group (n = 502) | Case group (n = 377) |
---|---|---|
Age (yrs) | 65.32 ± 14.83 | 69.92 ± 13.52 †|
Gender (male, %) | 41.2% | 48.3%* |
Hypertension (%) | 55.1% | 76.0%†|
Diabetes (%) | 24.6% | 37.4%†|
Ex-smoker/Current smoker (%) | 8.6%/17.7% | 8.7%/17.9% |
Race (Caucasian/African American/Asian-Indian/Hispanic/Asian-oriental/Others) (%) | ||
 | 81.7%/8.4%/3.0%/3.8%/0.8%/2.4%) | 68.4%/11.9%/5.8%/6.9%/4.0%/2.9%)†|
TOAST classification | Â | Â |
   Cardioembolism | NA | 24.1% |
   Large artery atherosclerosis | NA | 31.8% |
   Small vessel occlusion | NA | 24.1% |
   Others / unknown | NA | 19.9% |
Glu298Asp allele distribution G/T (2n) | 482/198 | 460/194 |
Intron 4 VNTR allele distribution a/b/c (2n) | 164/830/4 | 127/590/15†|
   Caucasian | 126/688/2 | 87/410/3 |
   African American | 23/57/2 | 20/57/11* |
   Asian-Indian | 3/27/0 | 7/36/1 |
   Hispanic | 5/33/0 | 9/41/0 |
   Asian-Oriental | 2/6/0 | 1/27/0 |
   Others | 5/19/0 | 3/19/0 |