Skip to main content

Table 2 Association analyses with tag-SNPs selected in candidate genes. Single point SNP analysis results of first step analysis of PITX1, H2AFY, and NEUROG1 in 116 families from the initial linkage scan. Base positions are indicated according to built 35 of the human genome sequence. MAF, minor allele frequency; perm, permutations; SNP, single nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium probability test. Association analysis was performed using the FBAT package.

From: Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis

 

SNP

Position (b35)

MAF (Allele)

HWE

Z-score (Allele)

P-value

PITX1

rs28330

134,380,433

0.37 (T)

0.65

2.483 (C)

0.0130

 

rs31210

134,388,918

0.21 (A)

1.00

1.136 (G)

0.2560

 

rs474853

134,392,990

0.47 (T)

<10-5

0.62 (C)

0.5351

 

rs3805663

134,394,099

0.31 (G)

1.00

2.741(A)

0.0061

 

rs1700488

134,402,776

0.08 (A)

1.00

2.343 (G)

0.0191

H2AFY

rs13163460

134,692,981

0.21 (T)

0.52

1.084 (G)

0.2784

 

rs6865399

134,702,478

0.10 (G)

1.00

1.294 (G)

0.1957

 

rs2292011

134,707,146

0.22 (T)

0.85

1.453 (C)

0.1462

 

rs1393082

134,734,972

0.39 (A)

0.89

2.004 (C)

0.0450

 

rs3776203

134,736,664

0.15 (T)

0.79

1.065 (C)

0.2869

NEUROG1

rs6596238

134,892,355

0.39 (A)

0.55

0.769 (A)

0.4419

 

rs245128

134,908,890

0.35 (A)

0.33

1.044 (G)

0.2963