A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort

Table 1 Nominally significant associations between prolactin (PRL) and prolactin receptor (PRLR) tagSNPs and breast cancer risk

SNP	AA		NH		JA		LA		WH		OR (95%CI)^a
	% cases	% controls	% cases	% controls	% cases	% controls	% cases	% controls	% cases	% controls
PRL
"BLOCK 2"
SNP 34	(rs9466314)
AA	85.96	90.80	99.07	100.00	100.00	100.00	97.90	98.44	100.00	99.54	ref
AT	13.45	8.73	0.93	0.00	0.00	0.00	2.10	1.56	0.00	0.46	1.54 (1.02–2.34)
TT	0.58	0.47	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.29 (0.18–9.22)
PRLR											P trend = 0.049
BLOCK 3
SNP 49	(rs34024951)
CC	51.63	46.57	93.4	88.97	86.76	86.19	84.34	83.77	84.96	84.02	ref
CT	43.03	42.79	6.60	11.03	12.77	13.81	15.06	15.18	14.79	15.30	0.92 (0.77–1.10)
TT	5.34	10.64	0.00	0.00	0.47	0.00	0.60	1.05	0.25	0.68	0.50 (0.30–0.83)
											*P trend = 0.032*

AA, African Americans; NH, Native Hawaiians; JA, Japanese Americans; LA, Latinas, WH, Whites.
^a ORs adjusted for age and ethnicity.
^b P-value for test of trend.

ISSN: 1471-2350