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Table 4 Tag SNP results for IL6 and IL12B regions.

From: The candidate genes TAF5L, TCF7, PDCD1 , IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

     

Multilocus test P -values

 

Exons

Sequencing source

Polyorphisms

Tag SNPs

Families

Cases and controls

IL12B

8

Seattle SNPs and in house (23 subjects)

33 (from Seattle)

4 (in house)

25 had a MAF ≥ 0.10

6

N/A

0.940

1,590 cases and 1,748 controls

IL6

6

Seattle SNPs (23 subjects)

49

12 had MAF ≥ 0.10

4

0.0231

3,320 parent-child trios

0.236

3,486 cases and 3,783 controls

  1. We selected tag SNPs from SNPs with a MAF ≥ 0.10. MAF = minor allele frequency.