|  | Alleles | Genotypes | |||
---|---|---|---|---|---|---|
TAF5L | C744A (rs3753886) | C | A | CC | CA | AA |
7,497 cases | 7,457 (49.7) | 7,537 (50.3) | 1,827 (24.4) | 3,803 (50.7) | 1,867 (24.9) | |
7,496 controls | 7,671 (51.2) | 7,321 (48.8) | 1,928 (25.7) | 3,815 (50.9) | 1,753 (23.4) | |
OR (95% CI) | 1.00 (reference) | 1.07 (1.02–1.12) | 1.00 (reference) | 1.05 (0.97–1.14) | 1.14 (1.04–1.25) | |
P |  | 7.32 × 10-3 |  | 0.0244 | ||
PDCD1 | 7146G>A (rs11568821) | G | A | GG | GA | AA |
7,888 cases | 13,966 (88.3) | 1,810 (11.7) | 6,196 (78.6) | 1,574 (20.0) | 118 (1.5) | |
8,858 controls | 15,846 (88.5) | 1,870 (11.5) | 7,088 (80.0) | 1,670 (18.9) | 100 (1.1) | |
OR (95% CI) | 1.00 (reference) | 1.10 (1.02–1.17) | 1.00 (reference) | 1.08 (1.00–1.17) | 1.32 (1.00–1.74) | |
P | Â | 0.0102 | Â | 0.0268 | ||
PDCD1 | 872C>T (rs2227981) | C | T | CC | CT | TT |
5,758 cases | 6,699 (58.2) | 4,817 (41.8) | 1,956 (34.0) | 2,787 (48.4) | 1,015 (17.6) | |
7,289 controls | 8,440 (57.9) | 6,138 (42.1) | 2,461 (33.8) | 3,518 (48.3) | 1,310 (18.0) | |
OR (95% CI) | 1.00 (reference) | 1.00 (0.95–1.06) | 1.00 (reference) | 1.00 (0.92–1.08) | 0.97 (0.87–1.07) | |
P | Â | 0.586 | Â | 0.760 | ||
TCF7 | Pro19Thr (rs5742913) | C | A | CC | CA | AA |
7,434 cases | 13,022 (87.6) | 1,846 (12.4) | 5,709 (76.8) | 1,604 (21.6) | 121 (1.6) | |
8,637 controls | 15,355 (88.9) | 1,919 (11.1) | 6,826 (79.0) | 1,703 (19.7) | 108 (1.3) | |
OR (95% CI) | 1.00 (reference) | 1.13 (1.06–1.22) | 1.00 (reference) | 1.13 (1.04–1.22) | 1.32 (1.01–1.73) | |
P |  | 4.16 × 10-4 |  | 1.91 × 10-3 | ||
IL12B | A1159C (rs3212227) | A | C | AA | AC | CC |
4,321 cases | 6,898 (79.8) | 1,744 (20.2) | 2,748 (63.6) | 1,402 (32.5) | 171 (4.0) | |
4,711 controls | 7,588 (80.5) | 1,834 (19.5) | 3,050 (64.7) | 1,488 (31.6) | 173 (3.7) | |
OR (95% CI) | 1.00 (reference) | 1.06 (0.98–1.14) | 1.00 (reference) | 1.06 (0.96–1.16) | 1.13 (0.90–1.42) | |
P | Â | 0.134 | Â | 0.324 | ||
IL6 | 174G>C (rs1800795) | G | C | GG | GC | CC |
7,785 cases | 8,726 (56.0) | 6,844 (44.0) | 2,928 (33.1) | 4,312 (48.7) | 1,612 (18.2) | |
8,852 controls | 10,168 (57.4) | 7,536 (42.6) | 2,456 (31.6) | 3,814 (49.0) | 1,515 (19.5) | |
OR (95% CI) | 1.00 (reference) | 1.05 (1.01–1.10) | 1.00 (reference) | 1.04 (0.97–1.12) | 1.11 (1.01–1.21) | |
P | Â | 0.0291 | Â | 0.0879 | ||
ICAM1 | G241R (rs1799969) | G | A | GG | GA | AA |
5,776 cases | 10,257 (88.8) | 1,295 (11.2) | 4,553 (78.8) | 1,151 (19.9) | 72 (1.3) | |
6,094 controls | 10,787 (88.5) | 1,401 (11.5) | 4,787 (78.6) | 1,213 (19.9) | 94 (1.54) | |
OR (95% CI) | 1.00 (reference) | 0.96 (0.89–1.05) | 1.00 (reference) | 1.00 (0.91–1.10) | 0.74 (0.54–1.02) | |
P | Â | 0.382 | Â | 0.179 | ||
TBX21 | His33Gln (rs2240017) | C | G | CC | CG | GG |
4,342 cases | 8,456 (97.4) | 228 (2.6) | 4,116 (94.8) | 224 (5.2) | 2 (0.1) | |
4,763 controls | 9,293 (97.6) | 233 (2.4) | 4,533 (95.2) | 227 (4.7) | 3 (0.1) | |
OR (95% CI) | 1.00 (reference) | 1.08 (0.89–1.30) | 1.00 (reference) | 1.08 (0.88–1.31) | 1.10 (0.16–7.54) | |
P | Â | 0.459 | Â | 0.759 | ||
IL23R | Arg381Gln (rs11209026) | G | A | GG | GA | AA |
6,087 cases | 11,413 (93.7) | 761 (6.3) | 5,343 (87.8) | 727 (11.9) | 17 (0.3) | |
6,303 controls | 11,776 (93.4) | 830 (6.6) | 5,499 (87.2) | 778 (12.3) | 26 (0.4) | |
OR (95% CI) | 1.00 (reference) | 0.93 (0.84–1.03) | 1.00 (reference) | 0.95 (0.85–1.06) | 0.67 (0.36–1.26) | |
P | Â | 0.183 | Â | 0.285 | ||
IRF5 | -3835 (rs2004640) | T | G | TT | TG | GG |
5,657 cases | 5,834 (51.6) | 5,480 (48.4) | 1,487 (26.3) | 2,860 (50.6) | 1,310 (23.2) | |
6,044 controls | 6,160 (51.0) | 5,928 (49.0) | 1,581 (26.2) | 2,998 (49.6) | 1,465 (24.2) | |
OR (95% CI) | 1.00 (reference) | 0.98 (0.93–1.03) | 1.00 (reference) | 1.03 (0.94–1.12) | 0.96 (0.86–1.06) | |
P | Â | 0.451 | Â | 0.353 | ||
CD40 | Kozak (rs1883832) | C | T | CC | CT | TT |
4,392 cases | 6,624 (75.4) | 2,160 (24.6) | 2,500 (56.9) | 1,624 (37.0) | 268 (6.1) | |
4,702 controls | 7,132 (75.8) | 2,272 (24.2) | 2,680 (57.0) | 1,772 (37.7) | 250 (5.3) | |
OR (95% CI) | 1.00 (reference) | 1.03 (0.96–1.10) | 1.00 (reference) | 0.97 (0.89–1.07) | 1.18 (0.97–1.42) | |
P | Â | 0.456 | Â | 0.162 |