Table 1 Gene information for candidate osteoporosis genes
Gene Symbol | Gene Name | Locus ID | NM_# | Genomic Size | Exon # |
|---|---|---|---|---|---|
BGLAP | Bone gamma-carboxyglutamate (gla) protein (osteocalcin) | 1q25-q31 | NM_000711 | 263037 | 8 |
CALCR | Calcitonin receptor | 7q21.3 | NM_001742 | 149952 | 13 |
IL6ST | Interleukin 6 signal transducer (gp130, oncostatin M receptor) | 5q11 | NM_002184 | 54069 | 17 |
LGALS3 | Lectin, galactoside-binding, soluble, 3 (galectin 3) | 14q21-q22 | NM_002306 | 16124 | 6 |
PPARG | Peroxisome proliferative activated receptor, gamma | 3p25 | NM_005037 | 146417 | 7 |
PTH | Parathyroid hormone | 11p15.3-p15.1 | NM_000315 | 3966 | 3 |
SP7 | Sp7 transcription factor(osterix) | 12q13.13 | NM_152860 | 9176 | 2 |
TGFBI | Transforming growth factor, beta-induced, 68 kDa | 5q31 | NM_000358 | 34810 | 17 |
AR | Androgen receptor | Xq11.2-q12 | NM_000044 | 180246 | 8 |
BMP7 | Bone morphogenetic protein 7 | 20q13 | NM_001719 | 95747 | 7 |
AHSG | Alpha 2 HS-glycoprotein | 3q27 | NM_001622 | 8219 | 7 |
BMP2 | Bone morphogenetic protein 2 | 20p12 | NM_001200 | 10563 | 3 |
BMP4 | Bone morphogenetic protein 4 | 14q22-q23 | NM_001202 | 7156 | 4 |
BMP6 | Bone morphogenetic protein 6 | 6p24-p23 | NM_001718 | 154718 | 7 |
CBFB | Core-binding factor, beta subunit | 16q22.1 | NM_022845 | 71907 | 6 |
CTSK | Cathepsin K | 1q21 | NM_000396 | 12126 | 8 |
DLX5 | Distal-less homeobox 5 | 7q22 | NM_005221 | 4436 | 3 |
IBSP | Integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | 4q21-q25 | NM_004967 | 12373 | 7 |
IL1RN | Interleukin 1 receptor antagonist | 2q14.2 | NM_000577 | 16123 | 5 |
LGALS1 | Lectin, galactoside-binding, soluble, 1 (galectin 1) | 22q13.1 | NM_002305 | 4165 | 4 |
MSX1 | Msh homeobox homolog 1 | 4p16.3-p16.1 | NM_002448 | 4053 | 3 |
MSX2 | Msh homeobox homolog 2 | 5q34-q35 | NM_002449 | 6300 | 2 |
PTHLH | Parathyroid hormone-like hormone | 12p12.1-p11.2 | NM_002820 | 9663 | 4 |
PTHR1 | Parathyroid hormone receptor 1 | 3p22-p21.1 | NM_000316 | 26052 | 16 |
RUNX1 | Runt-related transcription factor 1 | 21q22.3 | NM_001754 | 261497 | 8 |
SPP1 | Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I) | 4q21-q25 | NM_000582 | 7761 | 6 |
TWIST1 | Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) | 7p21.2 | NM_000474 | 2203 | 2 |
CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 20q13.1 | NM_005194 | 1837 | 1 |
CYP17A1 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | 10q24.3 | NM_000102 | 6885 | 8 |
CYP19A1 | Cytochrome P450, family 19, subfamily A, polypeptide 1 | 15q21.1 | NM_000103 | 129125 | 10 |
IL10 | Interleukin 10 | 1q31-q32 | NM_000572 | 4892 | 5 |
IL4 | Interleukin 4 | 5q31.1 | NM_000589 | 5996 | 4 |
NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4q24 | NM_003998 | 115989 | 24 |
VEGF | Vascular endothelial growth factor | 6p12 | NM_003376 | 14391 | 8 |
NPY2R | Neuropeptide Y receptor Y2 | 4q31 | NM_000910 | 8447 | 2 |
FGF2 | Fibroblast growth factor 2 | 4q26-q27 | NM_002006 | 71528 | 3 |
FOS | V-fos FBJ murine osteosarcoma viral oncogene homolog | 14q24.3 | NM_005252 | 3383 | 4 |
FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 19q13.32 | NM_006732 | 7184 | 4 |
SOX5 | SRY (sex determining region Y)-box 5 | 12p12.1 | NM_152989 | 1030149 | 18 |
SOX6 | SRY (sex determining region Y)-box 6 | 11p15.3 | NM_033326 | 506124 | 16 |
SOX9 | SRY (sex determining region Y)-box 9 | 17q24.3-q25.1 | NM_000346 | 5401 | 3 |
PTGER4 | Prostaglandin E receptor 4 (subtype EP4) | 5p13.1 | NM_000958 | 13804 | 3 |
CSK | C-src tyrosine kinase | 15q23-q25 | NM_004383 | 20790 | 13 |
FGF23 | Fibroblast growth factor 23 | 12p13.3 | NM_020638 | 11502 | 3 |
FOSL2 | Fos-like antigen 2 | 2p23-p22 | NM_005253 | 21736 | 4 |
REL | V-rel reticuloendotheliosis viral oncogene homolog (avian) | 2p13-p12 | NM_002908 | 41427 | 11 |
RELA | V-rel reticuloendotheliosis viral oncogene homolog A, p65 (avian) | 11q13 | NM_021975 | 8559 | 11 |
RELB | V-rel reticuloendotheliosis viral oncogene homolog B (avian) | 19q13.32 | NM_006509 | 36741 | 11 |
NFKB2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 10q24 | NM_002502 | 6805 | 23 |
ITGAV | Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 2q31-q32 | NM_002210 | 90828 | 30 |
JDP2 | Jun dimerization protein 2 | 14q24.3 | NM_130469 | 38320 | 4 |
NFATC1 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 18q23 | NM_172390 | 72406 | 8 |
PPP3CA | Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 4q24 | NM_000944 | 323767 | 14 |
CASR | Calcium sensing receptor | 3q21.1 | NM_000388 | 102813 | 7 |
ZNF675 | Zinc finger protein 675 | 19p12 | AB_209601 | 33969 | 4 |
TRAF6 | TNF receptor associated factor 6 | 11p12 | NM_004620 | 21100 | 7 |
CLCN7 | Chloride channel 7 | 16p13.3 | NM_001287 | 29668 | 25 |
DBI | Diazepam binding inhibitor (acyl-Coenzyme A binding protein) | 2q14.2 | NM_020548 | 5461 | 5 |
CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88 kDa | 3p21 | NM_001904 | 40935 | 15 |
TCF4 | Transcription factor 4 | 18q21.2 | NM_003199 | 360475 | 20 |
OMD | Osteomodulin | 9q22.31 | NM_005014 | 10023 | 3 |
DMP1 | Dentin matrix acidic phosphoprotein | 4q22.1 | NM_004407 | 14049 | 6 |
WIF1 | WNT inhibitory factor 1 | 12q14.3 | NM_007191 | 70681 | 10 |
MEPE | Matrix extracellular phosphoglycoprotein with ASARM motif (bone) | 4q22.1 | NM_020203 | 13807 | 4 |
CCR1 | Chemokine (C-C motif) receptor 1 | 3p21.31 | NM_001295 | 6101 | 2 |
ATP6V0D2 | ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d2 | 8q21.3 | NM_152565 | 55316 | 8 |
IL15 | Interleukin 15 | 4q31.21 | NM_172174 | 96859 | 8 |
VEGFC | Vascular endothelial growth factor C | 4q34.3 | BC_063685 | 109205 | 7 |
PTK2B | PTK2B protein tyrosine kinase 2 beta | 8p21.2 | NM_004103 | 147905 | 35 |
WNT9A | Wingless-type MMTV integration site family, member 9A | 1q42.13 | NM_003395 | 26903 | 4 |
PPARA | Peroxisome proliferative activated receptor, alpha | 22q13.31 | NM_001001928 | 93155 | 8 |
CAT | Catalase | 11p13 | NM_001752 | 33115 | 13 |
GPX1 | Glutathione peroxidase 1 | 3p21.3 | NM_201397 | 1181 | 1 |
ITGA1 | Integrin, alpha 1\ | 5q11.2 | NM_181501 | 165350 | 29 |
MITF | Microphthalmia-associated transcription factor | 3p14.2-p14.1 | NM_198159 | 228855 | 10 |
PLXNA2 | Plexin A2 | 1q32.2 | NM_025179 | 216898 | 32 |
PTGS2 | Prostaglandin-endoperoxide synthase 2 | 1q25.2-q25.3 | NM_000963 | 8588 | 10 |
SEMA7A | Semaphorin 7A, GPI membrane anchor | 15q22.3-q23 | NM_003612 | 23954 | 14 |
DKK1 | Dickkopf homolog 1 | 10q11.2 | NM_012242 | 3063 | 4 |
IL3 | Interleukin 3 (colony-stimulating factor, multiple) | 5q31.1 | NM_000588 | 2550 | 5 |
IL13 | Interleukin 13 | 5q31 | NM_002188 | 2937 | 4 |