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Table 2 Frequencies of investigated SOD2 polymorphisms in the 1996 NLTCS blood samples (N = 613–639).

From: SOD2polymorphisms: unmasking the effect of polymorphism on splicing

Nucleotide Position

Location

Genotype

African-American

White

36

Intron 1

A/A

19 (48.7%)

352 (61.9%)

  

A/G

19 (48.7)

198 (34.8%)

  

G/G

1 (2.6%)

19 (3.3%)

  

Total

39 (100%)

569 (100%)

  

H-W E

0.137

0.183

  

P

0.212

 

332

Exon 2

C/C*

5 (13.5%)

156 (27.2%)

  

C/T*

16 (43.3%)

270 (47.1%)

  

T/T*

16 (43.3%)

147 (25.7%)

  

Total

42 (100%)

573 (100%)

  

H-W E

0.755

0.184

  

P

0.044

 

8039

Intron 3

T/T

25 (59.5%)

231 (39.0%)

  

T/G

9 (22.4%)

225 (38.0%)

  

G/G

8 (19.1%)

136 (23.8%)

  

Total

42 (100%)

592 (100%)

  

H-W E

0.0016

<0.0001

  

P

0.031

 

8116

Intron 3

G/G

24 (57.1%)

232 (39.3%)

  

G/T

11 (26.2%)

222 (37.6%)

  

T/T

7 (16.7%)

137 (23.2%)

  

Total

42 (100%)

591 (100%)

  

H-W E

0.015

<0.0001

  

P

0.093

 

8134

Intron 3

T10/T10

36 (83.7%)

592 (99.3%)

  

T10/T9

7 (18%)

4 (0.7%)

  

T9/T9

0

0

  

Total

43 (100%)

592 (100%)

  

H-W E

0.544

0.934

  

P

< 0.0001

 
  1. Nucleotide numbering is according to the sequence of GenBank accession number NT_007422.
  2. H-W E are p values of Hardy-Weinberg equilibrium. P values show the probability of identical distribution between African-American and Non-African American groups.
  3. *C-to-T change will result in alanine (GCT) to valine (GTT) substitution at amino acid 16.