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Table 4 Population and family-based QTDT results for young cohort for the most significant variants among CHRM2 gene

From: Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study

position (bp)

Phenotype

NPOPULATION

χ2

P

GE

NFAMILY

χ2

P

GE

  

Population-based

Family-based

rs2350780

PIQ

366

0.74

0.390

1.34 (G)

95

1.81

0.179

3.63 (A)

(136243509)

VIQ

366

1.62

0.203

1.42 (G)

95

2.11

0.147

2.47 (A)

 

FSIQ

366

1.82

0.177

1.68 (G)

95

2.94

0.086

3.48 (A)

rs1364409

PIQ

362

0.13

0.718

0.57 (T)

96

0.67

0.413

2.33 (A)

(136262573)

VIQ

362

1.46

0.227

1.42 (T)

96

1.02

0.313

1.84 (A)

 

FSIQ

362

0.92

0.337

1.37 (T)

96

1.14

0.286

2.23 (A)

rs7782965

PIQ

346

0.17

0.680

0.77 (T)

85

0.18

0.671

2.00 (C)

(136274673)

VIQ

346

1.57

0.210

1.42 (T)

85

0.43

0.512

1.74 (C)

 

FSIQ

346

1.03

0.310

1.37 (T)

85

0.94

0.332

2.05 (C)

rs1378646

PIQ

366

0.00

1.000

0.00 (G)

98

0.20

0.655

1.26 (A)

(136214872)

VIQ

366

0.88

0.348

1.03 (G)

98

0.66

0.417

1.39 (A)

 

FSIQ

366

0.32

0.572

0.76 (G)

98

0.59

0.442

1.55 (A)

rs2061174

PIQ

363

0.01

0.920

0.19 (G)

111

0.41

0.522

1.69 (A)

(136311940)

VIQ

363

3.25

0.071

1.94 (G)

111

1.10

0.294

1.68 (A)

 

FSIQ

363

1.10

0.294

1.37 (G)

111

0.98

0.322

1.91 (A)

rs17411561

PIQ

345

1.20

0.273

1.91 (C)

85

0.23

0.632

1.47 (C)

(136332728)

VIQ

345

2.51

0.113

1.81 (C)

85

5.09

0.024

4.35 (C)

 

FSIQ

345

2.79

0.095

2.29 (C)

85

2.59

0.108

3.61 (C)

rs324640

PIQ

363

0.62

0.620

1.34 (G)

105

1.51

0.219

3.45 (A)

(136339536)

VIQ

363

2.83*

0.093

1.94 (G)

105

6.67

0.010

4.59 (A)

 

FSIQ

363

2.39

0.122

1.98 (G)

105

4.57

0.033

4.42 (A)

rs324650

PIQ

363

1.65

0.199

2.10 (T)

100

2.51

0.113

4.40 (T)

(136344201)

VIQ

363

4.56*

0.033

1.42 (T)

100

9.50

0.002

5.30 (T)

 

FSIQ

363

4.55

0.033

2.74 (T)

100

7.14

0.008

5.35 (T)

  1. *Stratification significant at P = 0.05
  2. Note: N denotes the number of individuals informative for the within family association test, i.e. those individuals that occur in families with more than one genotype. QTDT assumes equal genotypes for MZ twins and includes non-typed MZ co-twins with IQ scores. Abbreviation: GE genotypic effect (increaser allele).