Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population

Table 4 Association between 5 CFH haplotypes and premature heart disease

Haplotypes	Sequence	W¹	Expected(W)	Variance(W)	P-value
H1	CCGACG	133	131.9	47.9	0.88
H2	CCGAAG	279	280.4	97.5	0.89
H3	CTGGAG	181	184.5	61.6	0.66
H4	TTGAAA	167	167.7	58.5	0.92
H5	CTAAAG	166	161.5	56.6	0.55

¹ W = X+Y where X is the number of transmissions of the haplotype from heterozygote parents to affected siblings (TDT) and Y is the number of the occurrences of the haplotype in affected sibs in remaining informative families (S-TDT).
The 6 alleles in the Sequence column from left to right are from rs800292 to rs2284664 according to their positions in the CFH gene.

ISSN: 1471-2350