Previously described sequence variant in CDK5RAP2gene in a Pakistani family with autosomal recessive primary microcephaly

Table 1 Two-point LOD score results between the MCPH3 locus and chromosome 9 markers

			LOD score at recombination fraction θ =
Marker	Genetic distance*	Physical distance**	0.00	0.01	0.05	0.1	0.2	0.3
D9S1801	112.31	109425991	- inf	-2.73	-1.39	-0.85	-0.37	-0.14
D9S930	117.84	114276019	1.28	1.25	1.14	1.00	0.71	0.43
D9S302	122.69	N.A	1.58	1.54	1.39	1.19	0.82	0.47
D9S737	124.75	118592918	1.58	1.54	1.39	1.19	0.82	0.47
D9S762	126.40	120135547	1.58	1.54	1.39	1.19	0.82	0.47
D9S934	129.82	120135477	1.58	1.54	1.39	1.19	0.82	0.47
D9S1682	130.73	124033005	1.58	1.54	1.39	1.19	0.82	0.47
D9S242	133.72	125908748	1.58	1.54	1.39	1.19	0.82	0.47
D9S1881	141.5	126019246	0.96	0.95	0.89	0.79	0.57	0.33
D9S1847	147.72	134426754	- inf	-2.16	-0.89	-0.45	-0.13	-0.04

*-Cumulative sex-averaged Kosambi genetic map distances (cM) from the Rutgers combined linkage-physical map of the human genome [31].
**-Sequences-based physical map distances in bases according to NCBI Build 36.1 of the human reference sequence [32].

ISSN: 1471-2350