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Table 3 Frequencies of LPL SNPs according to form of dyslipidemia

From: The D9N, N291S and S447X variants in the lipoprotein lipase (LPL) gene are not associated with Type III Hyperlipidemia

D9N n DD DN NN N Freq
APOE2/2 patients      
ApoB (g/L)/TC (mmol/L) > 0.15 12 12 0 0 -
ApoB (g/L)/TC (mmol/L) < 0.15 88 85 3 0 0.015
Lipid clinic patients      
Hypertriglyceridemia (TC ≤ 200 mg/dl, TG > 150 mg/dl) n 89 82 7 0 0.039
Mixed hyperlipidemia (TC > 200 mg/dl, TG > 150 mg/dl) n 601 575 25 1 0.022
Familial defective ApoB (R3500Q carrier) n 52 50 2 0 0.019
Familial hypercholesterolemia (LDL > 330 mg/dl) n 41 38 3 0 0.036
Hypercholesterolemia (TC > 200 mg/dl, TG ≤ 150 mg/dl) 434 420 14 0 0.016
Normal (TC ≤ 200 mg/dl, TG ≤ 150 mg/dl) n 91 87 4 0 0.022
Blood Donors 200 188 12 0 0.03
N291S n NN NS SS S Freq
APOE2/2 patients      
ApoB (g/L)/TC (mmol/L) > 0.15 12 11 1 0 0.041
ApoB (g/L)/TC (mmol/L) < 0.15 88 83 5 0 0.026
Lipid clinic patients      
Hypertriglyceridemia (TC ≤ 200 mg/dl, TG > 150 mg/dl) n 89 78 9 2 0.073
Mixed hyperlipidemia (TC > 200 mg/dl, TG > 150 mg/dl) n 601 560 39 2 0.036
Familial defective ApoB (R3500Q carrier) n 52 49 3 0 0.029
Familial hypercholesterolemia (LDL > 330 mg/dl) n 41 40 1 0 0.012
Hypercholesterolemia (TC > 200 mg/dl, TG ≤ 150 mg/dl) 434 421 13 0 0.015
Normal (TC ≤ 200 mg/dl, TG ≤ 150 mg/dl) n 91 86 5 0 0.027
Blood Donors 200 193 7 0 0.018
S447X n SS SX XX X Freq
APOE2/2 patients      
ApoB (g/L)/TC (mmol/L) > 0.15 12 12 0 0 -
ApoB (g/L)/TC (mmol/L) < 0.15 88 71 16 1 0.092
Lipid clinic patients      
Hypertriglyceridemia (TC ≤ 200 mg/dl, TG > 150 mg/dl) n 89 84 5 0 0.028
Mixed hyperlipidemia (TC > 200 mg/dl, TG > 150 mg/dl) n 601 543 56 2 0.05
Familial defective ApoB (R3500Q carrier) n 52 43 9 0 0.087
Familial hypercholesterolemia (LDL > 330 mg/dl) n 41 34 6 1 0.096
Hypercholesterolemia (TC > 200 mg/dl, TG ≤ 150 mg/dl) 434 357 69 8 0.098
Normal (TC ≤ 200 mg/dl, TG ≤ 150 mg/dl) n 91 80 10 1 0.066
Blood Donors 200 166 34 0 0.085
  1. TC, total cholesterol; TG, triglycerides