Table 3 Analysis of PPAR alpha (L162V) in larger Caucasian only MRI cohort:
From: PPARα L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
Subcutaneous fat measure | Gender | SNP | N: adjusted mean ± SEM | P-value for significantly different means | Variability attributable to genotype | Likelihood-ratio test p-value * |
|---|---|---|---|---|---|---|
Full model – with age only adjustment | ||||||
Trained arm – baseline fat volume | Male | PPAR alpha (L162V) | CC (N = 179; 167221 ± 6710)* CG (N = 24; 207418 ± 18325) * | * p = 0.041 | 2.0% | 0.039 |
Trained arm – post-exercise fat volume | Male | PPAR alpha (L162V) | CC (N = 179; 170608 ± 6952)* CG (N = 24; 214926 ± 18932) * | *p = 0.029 | 2.3% | 0.028 |
Untrained arm – baseline fat volume | Male | PPAR alpha (L162V) | CC (N = 179; 169890 ± 7106)* CG (N = 24; 224144 ± 19407) * | *p = 0.033 | 2.2% | 0.031 |
Untrained arm – post-exercise fat volume | Male | PPAR alpha (L162V) | CC (N = 179; 168183 ± 7241)* CG (N = 24; 231960 ± 19776) * | *p = 0.003 | 4.2% | 0.003 |
Untrained arm – difference in fat volume | Male | PPAR alpha (L162V) | CC (N = 179; -1707 ± 2133)* CG (N = 24; 17617 ± 5826) * | *p = 0.002 | 4.6% | 0.002 |
Full model – with age and weight adjustment | ||||||
Untrained arm – difference in fat volume | Male | PPAR alpha (L162V) | CC (N = 179; -1921 ± 2134)* CG (N = 24; 17612 ± 5825) * | *p = 0.002 | 4.9% | 0.001 |