Pedigree structure of a Chinese family affected with type II DGI. Affected males and females are indicated by filled squares and circles, respectively. Normal individuals are shown as empty symbols. The proband is indicated by an arrow. Linkage analysis was performed with two polymorphic microsatellite markers, D4S414 and D4S1534 linked to the DSPP gene. Genotypic results are shown under each symbol. Note that haplotype 1–4 co-segregates with affected individuals, suggesting that the disease-causing gene in the family is linked to DSPP.