Table 1 Transmission disequilibrium tests of the SNPs in the INS, PTPN22, and CTLA4 gene in the T1D trio set used in this study
gene | dbSNP ID | minor allele (frequency) | Transmission ratio* | χ2 (p value) | OR (95% CI) |
|---|---|---|---|---|---|
INS | rs689 | T (0.207) | 186:387 | 70.5 (4.58 × 10-17) | 0.48 (0.40, 0.57) |
PTPN22 | rs2476601 | A (0.126) | 251:123 | 43.8 (3.62 × 10-11) | 2.04 (1.64, 2.53) |
CTLA4 | rs231775 | G (0.387) | 443:382 | 4.5 (0.034) | 1.16 (1.01, 1.33) |
CTLA4 | rs5742909 | T (0.090) | 137:178 | 5.3 (0.021) | 0.77 (0.62, 0.96) |