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Table 7 Genotype and allele frequencies of selected SNPs in case and control groups. The five TGFB1 SNPs were selected on the basis of previous publications [23-27]. The remaining two TGFBR2 SNPs were selected from potentially functional SNPs identified through screening the gene as summarised in Table 1. Data are n (%)

From: Resequencing of genes for transforming growth factor β1 (TGFB1) type 1 and 2 receptors (TGFBR1, TGFBR2), and association analysis of variants with diabetic nephropathy

SNP Genotype Case Control pvalue Allele Case Control pvalue
TGFB1 -800G>A GG 188 (69.1) 268 (73.0) 0.56 G 454 (83.5) 628 (85.6) 0.30
  GA 78 (28.7) 92 (25.1)      
  AA 6 (2.2) 7 (1.9)   A 90 (16.5) 106 (14.4)  
TGFB1 -509C>T CC 179 (65.8) 245 (66.8) 0.62 C 442 (81.3) 595 (81.1) 0.93
  CT 84 (30.9) 105 (28.6)      
  TT 9 (3.3) 17 (4.6)   T 102 (18.7) 139 (18.9)  
TGFB1 +72InsC - C 221 (81.3) 301 (82.0) 0.88 - C 488 (89.7) 663 (90.3) 0.71
  +/- C 46 (16.9) 61 (16.6)      
  + C 5 (1.8) 5 (1.4)   +C 56 (10.3) 71 (9.7)  
TGFB1 +869T>C TT 151 (55.5) 204 (55.6) 0.86 T 403 (74.1) 540 (73.6) 0.84
  TC 101 (37.1) 132 (36.0)      
  CC 20 (7.4) 31 (8.4)   C 141 (25.9) 194 (26.4)  
TGFB1 +915G>C GG 219 (80.5) 298 (81.2) 0.98 G 488 (89.7) 661 (90.1) 0.84
  GC 50 (18.4) 65 (17.7)      
  CC 3 (1.1) 4 (1.1)   C 56 (10.3) 73 (9.9)  
a TGFBR2 c.*747C>G CC 218 (90.5) 287 (89.1) 0.88 C 457 (94.8) 606 (94.1) 0.61
  CG 21 (8.7) 32 (9.9)      
  GG 2 (0.8) 3 (0.9)   G 25 (5.2) 38 (5.9)  
a TGFBR2 c.1149G>A GG 232 (96.3) 317 (98.4) 0.10 G 473 (98.1) 639 (99.2) 0.10
  GA 9 (3.7) 5 (1.6)      
  AA 0 0   A 9 (1.9) 5 (0.8)  
  1. a272 cases and 367 controls were genotyped for TGFB1 SNPs with 241 cases and 322 controls genotyped for TGFBR2 variants.