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Table 3 Sequence diversity parameters of human PNMT gene region

From: Resequencing PNMTin European hypertensive and normotensive individuals: no common susceptibilily variants for hypertension and purifying selection on intron 1

   

Estonians d

Czech d

 

kb

 

Hyper

Normo

All

Hyper

Normo

All

Sequenced area

3.187

Ï€a

0.00035

0.00039

0.00037

0.0030

0.00024

0.00027

  

θb

0.00035

0.00042

0.00036

0.00042

0.00035

0.00036

  

Dc

0.01342

-0.16433

0.04368

-0.72287

-0.75219

-0.56268

Gene

2.222

Ï€

0.00026

0.00031

0.00028

0.00032

0.00029

0.00031

  

θ

0.00020

0.00040

0.00035

0.00040

0.00030

0.00035

  

D

0.51545

-0.52876

-0.37972

-0.48106

-0.05656

-0.24179

Exons

1.157

Ï€

0.00050

0.00056

0.00052

0.00054

0.00050

0.00052

  

θ

0.00039

0.00058

0.00050

0.00058

0.00039

0.00050

  

D

0.51545

-0.07671

0.07805

-0.13715

0.50566

0.06616

Introns

1.065

Ï€

NA

0.00004

0.00002

0.00007

0.00007

0.00007

  

θ

NA

0.00021

0.00018

0.00021

0.00021

0.00018

  

D

NA

-1.10280

-1.02786

-0.87191

-0.87191

-0.68607

5'upstream region

0.882

Ï€

0.00114

0.00120

0.00116

0.00138

0.00099

0.00121

  

θ

0.00076

0.00076

0.00066

0.00101

0.00101

0.00088

  

D

1.03138

1.19760

1.38242

0.83180

-0.03929

0.74751

  1. Estimate of nucleotide diversity per site from aaverage pairwise difference among individuals and bnumber of segregating sites (S); cTajima's D statistics; dn = 25 for normotensives, n = 25 for hypertensives; NA – not applicable
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BMC Medical Genetics

ISSN: 1471-2350

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