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Figure 1 | BMC Medical Genetics

Figure 1

From: Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene

Figure 1

A schematic showing the intron-exon structure of ADAM33 and the location of CNSs toward the 5' end of the gene. The results are a comparison of human ADAM33 intron BC and the flanking sequence with the syntenic region of the mouse gene. The x axis corresponds to the human reference sequence (GenBank accession no: AF466288) and the y axis corresponds to the percent identity for a sliding window of 100 bp. Exons are labeled in blue and show high homology between the two species. Intronic regions >75% identical over at least 100 bp are shown in pink where there is a CNS region that is in close proximity to SNP BC+1 and two others that reside in intron AB. SNP BC+1 lies within a CNS that is >60% similar to the mouse. The promoter is in green showing the direction of transcription.

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BMC Medical Genetics

ISSN: 1471-2350

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